Results 201 to 210 of about 8,996,058 (264)

Machine learning research methods to predict postoperative pain and opioid use: a narrative review. [PDF]

Reg Anesth Pain Med
Langford DJ, Reichel JF, Zhong H, Basseri BH, Koch MP, Kolady R, Liu J, Sideris A, Dworkin RH, Poeran J, Wu CL.   +10 more
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Decolonization in sexual and reproductive health research methods: a scoping review. [PDF]

BMC Health Serv Res
Stevens-Uninsky M, Barkhad A, MacDonald T, Perez A, Mbuagbaw L.   +4 more
europepmc   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Reinforcing Primary Care in Korea: Policy Implications, Data Sources, and Research Methods. [PDF]

J Korean Med Sci
Kim CN, Yoon SJ.
europepmc   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Examining the research methods of early warning signals in clinical psychology through a theoretical lens. [PDF]

BMC Psychiatry
Cui J, Olthof M, Hasselman F, Lichtwarck-Aschoff A.   +3 more
europepmc   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Outcomes of Foundational Learning in Research Methods Following Primary Medical Qualification on Surgical Research: A Retrospective Review. [PDF]

ANZ J Surg
Patel M, Sun D, Starr MJ, Solanki D, Upadhyay J, Edwards DJA, Raju A, Maouris T, Lombardo A, Wang D, Nagi K, Bhimani N, Glover AR.   +12 more
europepmc   +1 more source