Results 51 to 60 of about 5,285,257 (310)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Coming of Age in Boston: Out-of-School Time Opportunities for Teens [PDF]
, 2004 Synthesizes findings from interviews, surveys, a literature review, and new research on current out-of-school time programs, what teens need and seek, and elements of effective programs.
Hedda Rublin +2 more
core
The 1995 NRC Ratings of Doctoral Programs: A Hedonic Model [PDF]
, 1996 We describe how one can use multivariate regression models and data collected by the National Research Council as part of its recent ranking of doctoral programs (Research-Doctorate Programs in the United States: Continuity and Change) to analyze how ...
Ehrenberg, Ronald G, Hurst, Peter J
core +2 more sources
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
BMC Public Health, 2020 Background Globally only 79% of adults living with HIV (human immunodeficiency virus) know their status and men in sub-Saharan Africa are considered a particularly hard-to-reach population for HIV testing.
Daisy Krakowiak +8 more
doaj +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Loss of mtDNA activates astrocytes and leads to spongiotic encephalopathy
Nature Communications, 2018 Astrocytes in the brain are metabolically dynamic. Here, Ignatenko, Chilov and colleagues delete mitochondrial DNA (mtDNA) in a cell type specific manner, and show that inactivation of mtDNA helicase Twinkle in astrocytes leads to spongiotic ...
Olesia Ignatenko +9 more
doaj +1 more source
First Nations Child and Family Services and Indigenous Knowledge as a Framework for Research, Policy and Practice [PDF]
, 2002 This paper provides an overview of the exciting national developments in First Nations child and family service delivery in Canada with a focus on progressive research, policy and practice.
Bennett, Marlyn, Blackstock, Cindy
core +1 more source
Coordinating Summer Undergraduate Research Programs for Expanding Diversity and Impact: Opportunities and Challenges [PDF]
, 2019 During summers 2015-2017, we operated a National Science Foundation (NSF) funded Research Experiences for Undergraduates (REU) Site, “Biomedical Engineering Community of Undergraduate Research Scholars for Cancer” (BME CUReS Cancer) at The University of ...
Cousins, Margo +3 more
core +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source