Results 71 to 80 of about 1,362,093 (249)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Liprin-α1 modulates cancer cell signaling by transmembrane protein CD82 in adhesive membrane domains linked to cytoskeleton

Cell Communication and Signaling, 2018
Background PPFIA1 is located at the 11q13 region commonly amplified in cancer. The protein liprin-α1 encoded by PPF1A1 contributes to the adhesive and invasive structures of cytoskeletal elements and is located at the invadosomes in cancer cells. However,
Henna Pehkonen, Mira Lento, Pernilla von Nandelstadh, Artemis Filippou, Reidar Grénman, Kaisa Lehti, Outi Monni   +6 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Human pluripotent reprogramming with CRISPR activators

Nature Communications, 2018
CRISPRa is an attractive tool for cellular reprogramming due to its multiplexing capacity and direct targeting of genomic loci. Here the authors demonstrate the reprogramming of human fibroblasts into iPSCs, which is enhanced by targeting a conserved Alu-
Jere Weltner, Diego Balboa, Shintaro Katayama, Maxim Bespalov, Kaarel Krjutškov, Eeva-Mari Jouhilahti, Ras Trokovic, Juha Kere, Timo Otonkoski   +8 more
doaj   +1 more source

Overview of medical physics education and research programs in a non-academic environment. [PDF]

J Appl Clin Med Phys, 2023
Fagerstrom JM, Brown TAD, Kaurin DGL, Mahendra S, Zaini MM.   +4 more
europepmc   +1 more source

Researching of Intelligence Test Paper Generation Software based on Improved Genetic Algorithm in Java Program Design Teaching [PDF]

, 2017
Qiufang Ma, Hao Pan
openalex   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Genome-wide quantification of copy-number aberration impact on gene expression in ovarian high-grade serous carcinoma

BMC Cancer
Copy-number alterations (CNAs) are a hallmark of cancer and can regulate cancer cell states via altered gene expression values. Herein, we have developed a copy-number impact (CNI) analysis method that quantifies the degree to which a gene expression ...
Sanaz Jamalzadeh, Jun Dai, Kari Lavikka, Yilin Li, Jing Jiang, Kaisa Huhtinen, Anni Virtanen, Jaana Oikkonen, Sakari Hietanen, Johanna Hynninen, Anna Vähärautio, Antti Häkkinen, Sampsa Hautaniemi   +12 more
doaj   +1 more source

Rockfish abundance, recruitment, and community structure trends in the western Strait of Juan de Fuca, Washington, 2005-2023

Frontiers in Marine Science
Rockfish, Sebastes spp., are bottomfish that come in a variety of shapes, sizes and colors with 28 species recognized in the Salish Sea. Based on increasing concern over the long-term stability of rockfish populations in Washington by state and federal ...
Shawn E. Larson, Katie Shelledy, Daniela Escontrela Dieguez, Jeff Christiansen, Amy Y. Olsen, Zachary Randell, Megan H. Williams, Chris VanDamme, Dayv Lowry, William Jasper   +9 more
doaj   +1 more source

Editorial: Examining community-engaged and participatory research programs and projects. [PDF]

Front Public Health, 2023
Eder MM, D'Alonzo KT, Yonas MA, Oetzel JG.   +3 more
europepmc   +1 more source