Results 91 to 100 of about 77,403,001 (321)

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Research Naval Postgraduate School, v.5, no. 1, April 1995

, 1995
NPS Research is published by the Research and Sponsored Programs, Office of the Vice President and Dean of Research, in accordance with NAVSOP-35.

core   +2 more sources

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Review Essay: Reporting Large-Scale Qualitative Research: The Ergography

Forum: Qualitative Social Research, 2008
As social science research programmes tend to increase in scale, reporting their results in a coherent manner is growing more difficult. Andrew WEBSTER's edited volume presents a wealth of social science research and is a pleasant read for many reasons ...
Bart Penders, Annemiek Nelis
doaj  

Endothelial Pim3 kinase protects the vascular barrier during lung metastasis

Nature Communications
Endothelial cells (ECs) form a tissue-specific barrier for disseminating cancer cells in distant organs. However, the molecular regulation of the ECs in the metastatic niche remains unclear.
Niina M. Santio, Keerthana Ganesh, Pihla P. Kaipainen, Aleksi Halme, Fatemeh Seyednasrollah, Emad Arbash, Satu Hänninen, Riikka Kivelä, Olli Carpen, Pipsa Saharinen   +9 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Impact of a stakeholder selected implementation strategy package – fast tracking, provider re-training, and co-location – on PrEP implementation for pregnant women in antenatal care clinics in western Kenya

Implementation Science Communications
Background Pre-exposure prophylaxis (PrEP) is recommended for HIV prevention in pregnant and postpartum women at substantial ongoing risk for HIV. In resource-limited settings, there exist gaps in the integration of PrEP into antenatal care.
Joseph Sila, Anjuli Dawn Wagner, Felix Abuna, Julia C Dettinger, Ben Odhiambo, Nancy Ngumbau, George Oketch, Enock Sifuna, Laurén Gómez, Sarah Hicks, Bryan J. Weiner, Grace John-Stewart, John Kinuthia   +12 more
doaj   +1 more source

Metabolomes of mitochondrial diseases and inclusion body myositis patients: treatment targets and biomarkers

EMBO Molecular Medicine, 2018
Mitochondrial disorders (MDs) are inherited multi‐organ diseases with variable phenotypes. Inclusion body myositis (IBM), a sporadic inflammatory muscle disease, also shows mitochondrial dysfunction.
Jana Buzkova, Joni Nikkanen, Sofia Ahola, Anna H Hakonen, Ksenia Sevastianova, Topi Hovinen, Hannele Yki‐Järvinen, Kirsi H Pietiläinen, Tuula Lönnqvist, Vidya Velagapudi, Christopher J Carroll, Anu Suomalainen   +11 more
doaj   +1 more source

Research directions in the clinical implementation of pharmacogenomics - An Overview of US programs and projects

Clinical pharmacology and therapy, 2018
Response to a drug often differs widely among individual patients. This variability is frequently observed not only with respect to effective responses but also with adverse drug reactions.
S. Volpi, Carol J. Bult, R. Chisholm, Patricia A. Deverka, G. Ginsburg, H. Jacob, M. Kasapi, H. L. McLeod, D. Roden, Marc S. Williams, Eric D. Green, L. Rodriguez, Samuel J. Aronson, L. Cavallari, J. C. Denny, L. Dressler, Julie A. Johnson, T. Klein, J. S. Leeder, M. Piquette-Miller, M. Perera, L. Rasmussen-Torvik, H. Rehm, M. Ritchie, T. Skaar, N. Wagle, R. Weinshilboum, Kristin W. Weitzel, R. Wildin, John M. Wilson, T. Manolio, M. Relling   +31 more
semanticscholar   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source