Results 111 to 120 of about 4,031,498 (261)

Computer program for stress, vibration, and buckling characteristics of general shells of revolution [PDF]

, 1973
Structures Research Associates (SRA) system of programs is composed of six compatible computer programs for structural analyses of axisymmetric shell structures.
Cohen, G. A., Haftka, R. T.
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

MICHIGAN APPLE COMMITTEE WINTER 2003 GROWER SURVEY: RESEARCH PROGRAMS [PDF]

Crop Production/Industries,
Aguilar, Cristobal, Thornsbury, Suzanne
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

The Nexus of HIV, substance abuse, and mental health among adolescents in Zambia (2021–2023)

Journal of Public Health in Africa
Background: Adolescents in Zambia face interrelated health challenges, including human immunodeficiency virus (HIV), substance abuse and mental health disorders (MHDs). These issues have significant public health implications, as substance abuse and MHDs
Belia Longwe, Lushomo Hachilensa, Chipwailia Chunga, Kutha Banda, Muchindu Ng’andu, Hilda Shakwelele, Trevor Mwamba, Nsanzya Maambo, Japhet Michelo, Prudence Haimbe, Mable Mweemba   +10 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Inhibiting cholesterol synthesis halts rhabdomyosarcoma growth via ER stress and cell cycle arrest

EMBO Molecular Medicine
Rhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma, with poor outcomes in high-risk and relapsed patients. Here, we identify de novo cholesterol biosynthesis as a critical metabolic vulnerability in RMS.
Nebeyu Yosef Gizaw, Kalle Kolari, Pauliina Kallio, Kari Alitalo, Riikka Kivelä   +4 more
doaj   +1 more source

A review of US Army aircrew-aircraft integration research programs [PDF]

If the U.S. Army's desire to develop a one crew version of the Light Helicopter Family (LHX) helicopter is to be realized, both flightpath management and mission management will have to be performed by one crew.
Aiken, E. W., Key, D. C.
core   +1 more source

Pipeline Programs [PDF]

, 2017
Pipeline programs are designed to prepare and inspire students to pursue careers in medicine and medical research. SKMC is committed to providing experiences and education to middle school, high school, college, and graduate students from groups ...

core   +1 more source

Research Programs in Japan [PDF]

Japanese Journal of Clinical Oncology, 1998
openaire   +2 more sources