Results 121 to 130 of about 4,031,498 (261)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

A live attenuated NS1-deficient vaccine candidate for cattle-origin influenza A (H5N1) clade 2.3.4.4.b viruses

npj Vaccines
Avian Influenza viruses (AIVs) present a public health risk, especially with seasonal vaccines offering limited protection. AIV H5N1 clade 2.3.4.4b has caused a multi-state outbreaks in the United States (US) poultry and cattle since March 2024, raising ...
Ahmed Mostafa, Chengjin Ye, Ramya S. Barre, Vinay Shivanna, Reagan Meredith, Roy N. Platt, Ruby A. Escobedo, Mahmoud Bayoumi, Esteban M. Castro, Nathaniel Jackson, Anastasija Cupic, Aitor Nogales, Timothy J. C. Anderson, Adolfo García-Sastre, Luis Martinez-Sobrido   +14 more
doaj   +1 more source

Assessing the Evidence About Work Support Benefits and Low-Income Families [PDF]

, 2011
Reviews research on factors affecting participation in work supports such as Medicaid, Children's Health Insurance, Supplemental Nutrition Assistance, and childcare subsidy programs; the programs' payoff, and state benefits of modernized delivery ...
Gregory Mills, Jessica F. Compton, Olivia Golden   +2 more
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Integrating oral pre-exposure prophylaxis delivery in primary care family planning clinics: a pragmatic, stepped-wedge, cluster-randomised trial

The Lancet Primary Care
Summary: Background: Integrating pre-exposure prophylaxis (PrEP) delivery in family planning settings might offer an efficient platform to reach women at increased risk for HIV. This study aimed to prospectively assess the effectiveness of a health-care
Kenneth K Mugwanya, MBChB, Daniel Matemo, MPH, Allison Meisner, PhD, Torin Schaafsma, MS, Jennifer Morton, MPH, Cynthia Wandera, BSN, Valarie Kemunto, BSN, Irine Cherotich, MSc, Stephen Odhiambo, Dip, Mercy Bii, Dip, Beatrice Oduor, Dip, Esther Achieng, Dip, Tecy Oyombra, Dip, David Owaga, BSc, Kristin M Beima-Sofie, PhD, ProfMD Jared M Baeten, PhD, John Kinuthia, MMed   +16 more
doaj   +1 more source

Implementation of R & QA practices in Research and Development programs [PDF]

DOE has established a number of broad programs aimed at reducing fuel consumption. Several programs address the R&D of ground transportation propulsion alternatives to the conventional spark-ignition engine.
Bankaitis, H.
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Physical Education Matters: A Full Report [PDF]

, 2008
Examines the quantity and quality of California's physical education programs, compliance with requirements, and resources. Summarizes research on the benefits of PE and effective strategies to improve PE programs.

core  

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source