Results 151 to 160 of about 61,346,701 (255)

Ten simple rules for providing effective bioinformatics research support. [PDF]

PLoS Comput Biol, 2020
Kumuthini J, Chimenti M, Nahnsen S, Peltzer A, Meraba R, McFadyen R, Wells G, Taylor D, Maienschein-Cline M, Li JL, Thimmapuram J, Murthy-Karuturi R, Zass L.   +12 more
europepmc   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Impact of the Oklahoma IDeA Network of Biomedical Research Excellence research support and mentoring program for early-stage faculty.

Adv Physiol Educ, 2022
Chou AF, Hammon D, Akins DR.
europepmc   +1 more source

Blending research support and mentorship to foster scholarly activity at a resource-limited institution. [PDF]

Paediatr Child Health, 2020
Tumin D, Buckman C, Kuehn D, Higginson JD.   +3 more
europepmc   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Indus Flood Research Project : lessons for climate change adaptation; field research report - district Charsadda

, 2012
Appendix B - final technical reportTwo research sites, the village Agra Payan UC Agra and Village Kharkai UC Daulat Pura were identified based on criteria developed by the Institute for Social and Environmental Transition (ISET) in collaboration with ...
Sarhad Rural Support Programme (SRSP)
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Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

A qualitative evaluation of the Research Equity and Diversity Initiative's (READI) research support voucher program and its community engagement support. [PDF]

J Clin Transl Sci
Muhigaba PB, Sperling J, Taylor S, Freel SA, Sutton LC, Snyder DC, Quenstedt S, Naggie S, Barrett NJ, Boulware LE.   +9 more
europepmc   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

National Mental Health Research Strategy [PDF]

This first national mental health research strategy for Ireland presents a unique opportunity to create a thriving mental health research system that can support mental health and wellbeing for all.
Health Research Board
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