Results 161 to 170 of about 61,346,701 (255)

A Successful Budget Strategy for Supporting a Centralized Graduate Medical Education Research Support Team. [PDF]

J Grad Med Educ
Kram JJF, Bidwell J, Vedder LS, Baumgardner DJ, Delfinado L, Simpson D, Deal J, La Fratta T, Hansen T.   +8 more
europepmc   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Male and Female Infertility in the Quest for Research Support and Public Health Interest: Analysis of Two Large Databases. [PDF]

Cureus
Tinsley SA, Considine J, Olabode S, Nzasi J, Lalchandani K, Assani K, Dabaja AA, Rambhatla A, Shish L, Hubbard LC.   +9 more
europepmc   +1 more source

Perspectives of Singaporean biomedical researchers and research support staff on actual and ideal IRB review functions and characteristics: A quantitative analysis. [PDF]

PLoS One, 2020
Labude MK, Shen L, Zhu Y, Schaefer GO, Ong C, Xafis V.   +5 more
europepmc   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Navigating the bench to bedside maze: Lessons from CTSA hubs on streamlining research support in academic medical centers. [PDF]

J Clin Transl Sci
Pope L, Chang B, McClave M, O'Byrne SM, Muhammad K, Abedin Z, Purcell M, Nair A, Zalcgendler K, Reilly MP.   +9 more
europepmc   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Application of machine learning techniques in GlaucomAI system for glaucoma diagnosis and collaborative research support. [PDF]

Sci Rep
Świerczyński H, Pukacki J, Szczęsny S, Mazurek C, Wasilewicz R.   +4 more
europepmc   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source