Results 111 to 120 of about 50,127 (263)

The pyruvate generator is a common phenomenon in mitochondria from different rat and mouse brain regions

FEBS Letters, EarlyView.
The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber, Niki Karavasili, Matthias Kunz, Zemfira Gizatullina, Timur Gainutdinov, Stefan Vielhaber, Wolfram S. Kunz, Frank N. Gellerich   +7 more
wiley   +1 more source

An Evaluation of Staff Training in Positive Behaviour Support [PDF]

, 2016
AIMS: Challenging behaviour is common for many people with learning disabilities and has a negative impact on the lives of these individuals. It is linked to decreased levels of support from staff, reduced opportunities for inclusion in the community ...
MacDonald, Anne
core  

Centre for Epidemic Interventions Research (CEIR), Annual Report 2022 [PDF]

, 2023
Key message During the COVID-19 pandemic it became apparent that the scientific basis for many infection control interventions was weak, and that more research on the effects of public health and social measures was needed.
Fretheim, Atle
core  

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Improving browsing in digital libraries with keyphrase indexes

, 1999
Browsing accounts for much of people's interaction with digital libraries, but it is poorly supported by standard search engines. Conventional systems often operate at the wrong level, indexing words when people think in terms of topics, and returning ...
Gutwin, Carl, Paynter, Gordon W., Nevill-Manning, Craig G., Witten, Ian H., Frank, Eibe   +4 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Imagination, mereotopology, and topic expansion [PDF]

Funding: The research and writing of this paper was supported by Cotnoir’s UKRI Frontier Research Grant, Instruments of Unity, Project Number 10004484. Aybuke Ozgun’s contribution received support from the project ‘The Logic of Conceivability’, funded by
Cotnoir, A. J., Özgün , Aybüke
core   +1 more source

Academic writing challenges and supports for early-stage Chinese postgraduates: A mixed-methods study on teaching-research integration, supervisor engagement, and self-efficacy.

PLoS ONE
Enhancing academic publication outcomes and writing skills in postgraduates is a key goal for higher education institutions, ideally through early intervention.
HuanHuan Zhang, XiaoShu Xu, Vivian Ngan-Lin Lei, Wilson Cheong Hin Hong, Weng Jie   +4 more
doaj   +1 more source

Research on the Application of Topic Models Based on Geological Disaster Information Mining

Information
Geological disasters, as a common occurrence, have a serious impact on social development in terms of their frequency of occurrence, disaster effects, and resulting losses.
Gang Cheng, Qinliang You, Gangqiang Li, Youcai Li, Daisong Yang, Jinghong Wu, Yaxi Wu   +6 more
doaj   +1 more source