Results 101 to 110 of about 107,049,564 (303)

Translophagy—A potential link between autophagy impairment and translational errors

open access: yesFEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk   +11 more
wiley   +1 more source

THE JOURNAL OF FOOD DISTRIBUTION RESEARCH: A 15-YEAR PERSPECTIVE, 1984-1998 [PDF]

open access: yes
In order to identify future implications for research in a discipline, it is sometimes necessary to investigate areas that have been examined previously.
Corbett, James J.
core  

Navigating through archives, libraries and museums: Topic Maps as a harmonizing instrument [PDF]

open access: yes, 2005
The paper deals with the possibility of creating a topic map based system where different sectors of cultural heritage would interact with users, by monitoring the navigation histories of users and the statistics on the searches, in order to authorize ...
Vassallo, Salvatore
core   +1 more source

Competências científico- tecnológicas e cooperação universidade-empresa na saúde

open access: yesRevista de Saúde Pública
OBJETIVO: Analisar a evolução recente das competências científicas na área de saúde, o efeito das linhas de fomento na redução dos desequilíbrios científicos regionais e a interação universidade-empresas entre os grupos de pesquisa em saúde no Brasil ...
Jorge Britto   +3 more
doaj  

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Free Model of Sentence Classifier for Automatic Extraction of Topic Sentences

open access: yesJournal of ICT Research and Applications, 2013
This  research  employs  free  model  that  uses  only  sentential  features without paragraph context  to extract topic sentences of a paragraph. For finding optimal  combination  of  features,  corpus-based  classification  is  used  for constructing a
M.L. Khodra   +3 more
doaj  

Basic Methodological Considerations on the Digitalisation as Research Topic Choice and Justification on the Research Topic and Rule of Thumbs for a Scientific Title, Keywords and Abstract-Writing, Supported by a Collection of Student Materials

open access: yesKöz-gazdaság, 2019
There can be research themes that may seem to be odd or alien for the first sight, hence they can discourage potential authors from further work. For many of our students in 2018, in the Institute of World Economy, that was digitalisation. However, as a research topic it appears at three levels: micro, mezzo and macro, and tends to become a grand ...
openaire   +4 more sources

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

Child Support Services Handbook

open access: yes, 2013
application/pdfThe Kansas Child Support Services (CSS) program helps children receive the financial support necessary for their growth and development.
Kansas Child Support Services.
core  

Home - About - Disclaimer - Privacy