Results 81 to 90 of about 50,127 (263)

Holistic engineering design : a combined synchronous and asynchronous approach

, 2008
To aid the creation and through-life support of large, complex engineering products, organizations are placing a greater emphasis on constructing complete and accurate records of design activities.
Lynn, Andrew, M. D. Giess, C. A. McMahon, Giess, M. D., Ding, L., L. Ding, Ding, L, W. J. Ion, Y. M. Goh, Conway, Alastair, Lynn, A., McMahon, Chris, Giess, M, Goh, Yee M, Goh, Y. M., Ion, W. J., A. P. Conway, A. Lynn, Conway, A. P., McMahon, C. A., Ion, William   +20 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Exploring the support needs of Pakistani families with disabled children: A participatory action research study

, 2009
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Pakistani families with disabled children are among the most disadvantaged population groups in the UK.
Kramer-Roy, Debbie
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Designing for learning and support: The user-centred construction and evaluation of an on-line environment for Malaysian teachers learning about digital graphics [PDF]

, 2008
This research focused on the importance of user context in designing learning and support in an online learning environment since the increase of the use of online learning environment had produced several problems and perceptions among students ...
Yahaya, Noraffandy
core  

Vignette development and administration:A framework for protecting research participants

, 2012
This paper is a discussion regarding vignette development and administration as a means of protecting research participants in social research. Health and social care researchers investigate a plethora of issues that may be sensitive or upsetting, for ...
Taylor, J., Taylor, Julie; id_orcid, Herber, O.R, Herber, O.R., Herber, O. R., Bradbury-Jones, C., Bradbury-Jones, Caroline, Taylor, Julie   +7 more
core   +1 more source

Building a Document Genre Corpus: a Profile of the KRYS I Corpus [PDF]

, 2008
This paper describes the KRYS I corpus (http://www.krys-corpus.eu/Info.html), consisting of documents classified into 70 genre classes. It has been constructed as part of an effort to automate document genre classification as distinct from topic ...
Berninger, Vera, Yunhyong Kim, Ross, Seamus, V. F. Berninger, Kim, Yunhyong, Seamus Ross   +5 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source