Results 121 to 130 of about 107,049,564 (303)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

On prospective instruments for financial support of economic entities in carrying out applied research

, 2018
Quite a number of researchers have addressed the topic of the instruments of inancial support for economic entities. In their works they use various approaches to the classiication of such instruments.
Blagoveshchenskaya AS, Sergeeva OL
core   +1 more source

A temporal adaptive dictionary-constrained LDA and Bi-calibrated dual granularity DTM framework for dynamic topic evolution analysis in academic papers

Scientific Reports
With the explosive growth of academic achievements in artificial intelligence (AI), accurately capturing the dynamic evolution of research topics is crucial for research topic selection, policy-making, and industrial innovation. To address the limitation
Xueqi Yin
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Academic legal research and academic research capacity enhancement working topic : "purposes and objectives of law schools beyond educating students (research, capacity building,community service and outreach)"\ud \ud [PDF]

, 2009
One of the main objectives of law schools beyond educating students is to produce viable legal research. The comments in this paper are basically confined to the Australian context, and to examine this topic effectively, it is necessary to briefly review
Hutchinson, Terry C.
core  

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Environmental monitoring and analysis in support of Antrim oil shale research. Topical report, March 1978-February 1979

, 1979
A program to assess environmental impacts of in situ Antrim oil shale processing experiments was carried out. This report covers the second year of an expected four year program. Activities included: monitoring of surface elevations for possible subsidence; monitoring for soil contamination from brines; monitoring surface and subsurface water quality ...
F. J. Tanis, G. S. Thomas
openaire   +2 more sources

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

What makes an Allergen an Allergen?

, 2022
The IgE-mediated immune response to allergens affect approximately 25% of the population of industrialized nations. They are characterized by elevated levels of serum IgE and a Th2-biased immune response to proteins that are often abundant and harmless ...
Maria Antonietta Ciardiello, Coeditors of a Research Topic Soheila June Maleki, Brian Sutton, Maksymilian Chruszcz   +3 more
core