Results 151 to 160 of about 69,816,536 (306)

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

open access: yesMolecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir   +9 more
wiley   +1 more source

Bibliometric analysis of public health research in Africa: The overall trend and regional comparisons

open access: yesSouth African Journal of Science, 2011
Many diseases in Africa can be prevented with appropriate public health interventions. This study aimed to assess the bibliometric characteristics of public health related research articles published by researchers in African institutions from 1991 to ...
Kun-Yang Chuang   +3 more
doaj  

Global Research Trend in Vaccine Design. [PDF]

open access: yesVaccines (Basel), 2022
Trivedi D   +3 more
europepmc   +1 more source

Behaviour of Dickey-Fuller Unit Root Tests Under Trend Misspecification [PDF]

open access: yes
We analyse the case where a unit root test is based on a Dickey-Fuller regression whose only deterministic term is a fixed intercept. Suppose, however, as could well be the case, that the actual data generating process includes a broken linear trend.
Tae-Hwan Kim   +2 more
core  

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

open access: yesMolecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

open access: yesMolecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna   +8 more
wiley   +1 more source

Dynamic Visualization of Computer-Aided Peptide Design for Cancer Therapeutics

open access: yesDrug Design, Development and Therapy
Dan Hou,1– 3,* Haobin Zhou,1,2,* Yuting Tang,1,2 Ziyuan Liu,1,2 Lin Su,1,2 Junkai Guo,1,2 Janak Lal Pathak,1,2 Lihong Wu1,2 1Department of Basic Oral Medicine, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral ...
Hou D   +7 more
doaj  

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