Results 91 to 100 of about 66,430,318 (252)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Testing for a unit root in the presence of a possible break in trend [PDF]

In this paper we consider the issue of testing a time series for a unit root in the possible presence of a break in a linear deterministic trend at some unknown point in the series.
David I. Harvey, Stephen J. Leybourne, David Harris, A. M. Robert Taylor   +3 more
core  

GMT-24-script-trend-south

, 2019
GMT-24-script-trend ...
Polina Lemenkova (5855411)
core   +1 more source

IMPACT OF MATERNAL CHILDHOOD TRAUMA ON METABOLIC COMPOSITION AND MICRORNA CONTENT OF HUMAN MILK

IBRO Neuroscience Reports, 2023
Patrycja Chudzicka-Ormaniec, Magdalena Gomółka, Weronika Tomaszewska, Anna Ziomkiewicz-Wikary, Ali Jawaid   +4 more
doaj   +1 more source

Current trends and emerging patterns in the application of nanomaterials for ovarian cancer research: a bibliometric analysis

Frontiers in Pharmacology
Introduction: Ovarian cancer remains to be a significant cause of global cancer-related mortality. In recent years, there has been a surge of studies in investigating the application of nanomaterials in the diagnosis and treatment of ovarian cancer. This
Wenhui Wang, Jie Wei, Dingqing Feng, Bin Ling   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Multivariate trend comparisons between autocorrelated climate series with general trend regressors [PDF]

Inference regarding trends in climatic data series, including comparisons across different data sets as well as univariate trend significance tests, is complicated by the presence of serial correlation and step-changes in the mean.
Timothy Vogelsang, Ross McKitrick
core  

Comments on: Huang et al. (2019) Emerging trends and research foci in gastrointestinal microbiome’, J. Transl. Med., 17: 67

Journal of Translational Medicine, 2020
Yuh-Shan Ho
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Trend Inflation, Wage Indexation, and Determinacy in the U.S. [PDF]

We combine an estimated monetary policy rule featuring time-varying trend inflation and stochastic coefficients with a medium scale New Keynesian framework calibrated on the U.S. economy.
Nicola Branzoli, Efrem Castelnuovo, Guido Ascari   +2 more
core