Results 161 to 170 of about 2,252,872 (309)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Dynamic Visualization of Computer-Aided Peptide Design for Cancer Therapeutics

Drug Design, Development and Therapy
Dan Hou,1– 3,* Haobin Zhou,1,2,* Yuting Tang,1,2 Ziyuan Liu,1,2 Lin Su,1,2 Junkai Guo,1,2 Janak Lal Pathak,1,2 Lihong Wu1,2 1Department of Basic Oral Medicine, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral ...
Hou D, Zhou H, Tang Y, Liu Z, Su L, Guo J, Pathak JL, Wu L   +7 more
doaj  

Triangulating the link between depression and liver disease: An integrative analysis of genetic, observational, and research trend data. [PDF]

Compr Psychoneuroendocrinol
Feng Z, Wang Y, Lu Q, Jin X, Qin Y, Jiang Y, Chen X, Li K.   +7 more
europepmc   +1 more source

Correction: Data Analysis of Physician Competence Research Trend: Social Network Analysis and Topic Modeling Approach. [PDF]

JMIR Med Inform, 2023
Yune SJ, Kim Y, Lee JW.
europepmc   +1 more source

Powerful Trend Function Tests That are Robust to Strong Serial Correlation with an Application to the Prebisch Singer Hypothesis [PDF]

In this paper we propose tests for hypothesis regarding the parameters of a the deterministic trend function of a univariate time series. The tests do not require knowledge of the form of serial correlation in the data and they are robust to strong ...
Helle Bunzel, Timothy Vogelsang
core  

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Comment on "Global research trend of graphene application in breast cancer: a bibliometric analysis". [PDF]

Int J Surg
Liu Y, Yang H, Peng J, Zhao Y.
europepmc   +1 more source

The global landscape and research trend of phase separation in cancer: a bibliometric analysis and visualization. [PDF]

Front Oncol, 2023
Li M, Zhang Y, Zhao J, Wang D.
europepmc   +1 more source

Research trend of technology innovation from 1971 to 2024: A bibliometric analysis [PDF]

Purpose – The aim of this paper is to present a detailed analysis of the Technology Innovation literature published in the Scopus database from 1971 to 2024, determining the trends in the field of technology innovation and its maturity as an academic ...
Mohamad Dasuki, Norhafizah, Atan, Nur Atika, Jumbri, Isma Addi, Fauzan   +3 more
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source