Results 101 to 110 of about 5,617,166 (283)

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Magnetic field effect on Poiseuille flow and heat transfer of carbon nanotubes along a vertical channel filled with Casson fluid

AIP Advances, 2017
Applications of carbon nanotubes, single walls carbon nanotubes (SWCNTs) and multiple walls carbon nanotubes (MWCNTs) in thermal engineering have recently attracted significant attention.
Sidra Aman, Ilyas Khan, Zulkhibri Ismail, Mohd Zuki Salleh, Ali Saleh Alshomrani, Metib Said Alghamdi   +5 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Investigating the role of gut microbiome in the association between ambient air pollution and type-2 diabetes mellitus: a causal inference approach using review of evidence to date

Frontiers in Environmental Health
Pollutants in ambient air have been linked with type-2 diabetes mellitus (T2DM) in low as well as high pollution scenarios. Mechanisms of action include disruption of endothelial function, imbalance in the autonomic nervous system and direct ...
Siddhartha Mandal, Siddhartha Mandal, Steena Kuriakose, Krithiga Shridhar, Krithiga Shridhar   +4 more
doaj   +1 more source

Lead Poisoning and The Bell Curve [PDF]

A robust environmental health literature demonstrates that preschool lead exposure can cause neurodevelopmental damage and associated adverse impacts on IQ, education, and behavior.
Nevin, Rick
core   +1 more source

Organic Trends [PDF]

, 2005
ORGANIC TRENDS aims to promote environmentally friendly and healthy food production and processing in China. Offering a forum for producers, sitributors, retailers, consumers as well as academicians, it reports recent trends in organic farming and food ...
Sternfeld, Eva
core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

A simple but tough-to-beat baseline for fMRI time-series classification

NeuroImage
Current neuroimaging studies frequently use complex machine learning models to classify human fMRI data, distinguishing healthy and disordered brains, often to validate new methods or enhance prediction accuracy.
Pavel Popov, Usman Mahmood, Zening Fu, Carl Yang, Vince Calhoun, Sergey Plis   +5 more
doaj   +1 more source