Results 71 to 80 of about 5,617,166 (283)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Worldwide Research Trends on Wheat and Barley: A Bibliometric Comparative Analysis [PDF]

, 2019
Grain cereals such as wheat, barley, rice, and maize are the nutritional basis of humans and animals worldwide. Thus, these crop plants are essential in terms of global food security.
Benavente Barzana, María Elena, Giménez Caminero, Estela, Giraldo Carbajo, Patricia, Manzano Agugliaro, Francisco   +3 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Integrating fMRI spatial network dynamics and EEG spectral power: insights into resting state connectivity

Frontiers in Neuroscience
IntroductionThe Integration of functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) has allowed for a novel exploration of the brain’s spatial–temporal resolution.
Souvik Phadikar, Krishna Pusuluri, Armin Iraji, Vince D. Calhoun   +3 more
doaj   +1 more source

Trends in Bilateral and Multilateral Funding [PDF]

, 2010
Trends in Bilateral and Multilateral Funding is part of the 2009-2010 FundHer Research Update brief series, produced by AWID's "Where is the Money for Women's Rights" Action-Research Initiative.
Alexandra Pittman, Cindy Clark, Lydia Alpízar, Sarah Rosenhek, Verónica Vidal   +4 more
core  

Trends in Seaweed Research [PDF]

, 2006
This is a letter on the evolution of trends in seaweed research with respect to the development of technology and generation of knowledge, as well as difficulties and future perspectives in seaweed ...
Abdullah, Luqman Chuah, Chin, Kit Ling, H'ng, Paik San, Tay, Pei Wen, Wong, Lih Jiun   +4 more
core   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Deciphering multiway multiscale brain network connectivity from birth to 6 months

Communications Biology
Converging evidence suggests that understanding the human brain requires more than just examining pairwise functional brain interactions. The human brain is a complex, nonlinear system, and focusing solely on linear pairwise functional connectivity often
Qiang Li, Zening Fu, Hasse Walum, Masoud Seraji, Prerana Bajracharya, Vince D. Calhoun, Sarah Shultz, Armin Iraji   +7 more
doaj   +1 more source