Results 111 to 120 of about 1,823,507 (396)

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Clinicopathological determinants of an elevated systemic inflammatory response following elective potentially curative resection for colorectal cancer [PDF]

, 2017
Introduction: The postoperative systemic inflammatory response (SIR) is related to both long- and short-term outcomes following surgery for colorectal cancer.
Horgan, Paul G., McMillan, Donald C., McSorley, Stephen T., Park, James H., Ramanathan, Michelle L., Walley, Killian, Watt, David G.   +6 more
core   +2 more sources

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Moderate sedation with single-dose remimazolam tosilate in elderly male patients undergoing transurethral resection of the prostate with spinal anesthesia: a prospective, single-arm, single-centre clinical trial [PDF]

, 2022
Tang‐yuan‐meng Zhao, Di Chen, Sun Hu, Zhi-xin Xu, Song Lyu, Tao Wang, Lili Liu   +6 more
openalex   +1 more source

NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao, Shikuan Din, Zhengkang Fu, Qian Sun, Xiwei Zhu, Yuxin Wei, Huan Qu, Xinyi Zhang, Jiaxuan Liu, Chuhua Fu, Qianxue Chen   +10 more
wiley   +1 more source

Immunohistochemical Staining on an Excision Biopsy Specimen as a Diagnostic Modality for Rare Idiopathic Hepatocellular Adenoma: A Case Report

Acta Medica Indonesiana, 2019
Hepatocellular adenoma is an extremely rare benign tumor of the liver which predominantly in young women. Its rare incidence with estimated 3-4 cases per 1.000.000 annually makes it a diagnostic challenge.
Juferdy Kurniawan, Andri Sanityoso, Toar JM Lalisang, Ening Krisnuhoni, Sahat Matondang, Abirianty P Araminta, Lutfie Lutfie   +6 more
doaj  

Serum IgG4-Negative Focal Autoimmune Pancreatitis Type 1 That Was Difficult to Diagnose Preoperatively Even with Frequent Endoscopic Ultrasound-Guided Fine-Needle Aspiration and Fine-Needle Biopsy: A Surgical Case Report

Case Reports in Gastroenterology
Introduction: Focal autoimmune pancreatitis (AIP) without elevated serum IgG4 levels presents a diagnostic challenge compared to pancreatic tumors, often leading to surgical intervention.
Shoichiro Mizukami, Koji Imai, Hiroki Takahata, Hiroyuki Takahashi, Shingo Shimada, Yuki Kamikokura, Hidemasa Kawabata, Mishie Tanino, Yusuke Mizukami, Hideki Yokoo   +9 more
doaj   +1 more source

Outcomes and risk score for distal pancreatectomy with celiac axis resection (DP-CAR) : an international multicenter analysis [PDF]

, 2019
Background: Distal pancreatectomy with celiac axis resection (DP-CAR) is a treatment option for selected patients with pancreatic cancer involving the celiac axis.
Adham, Mustapha, Bassi, Claudio, Berrevoet, Frederik, Besselink, Marc G, Boggi, Ugo, Busch, Olivier R, Cesaretti, Manuela, Dalla Valle, Raffaele, Darnis, Benjamin, Del Chiaro, Marco, Diener, Markus K, Dumitrascu, Traian, Friess, Helmut, Fusai, Giuseppe K, Gerritsen, Sarah L, Gruetzmann, Robert, Hackert, Thilo H, Hirono, Seiko, Hogg, Melissa E, Ivanecz, Arpad, Javed, Ammar A, Karayiannakis, Anastasios, Kawai, Manabu, Kleeff, Jorg, Klompmaker, Sjors, Labori, Knut J, Lesurtel, Mickael, Lombardo, Carlo, Lopez-Ben, Santiago, Mabrut, Jean-Yves, Miyazawa, Motoki, Moser, A James, Niesen, Willem, Okada, Ken-ichi, Pardo, Fernando, Perinel, Julie, Peters, Niek A, Popescu, Irinel, Prasad, Raj, Roeyen, Geert, Salvia, Roberto, Sauvanet, Alain, Sturesson, Christian, Teresa Albiol, M, Van Gulik, Thomas M, Van Hilst, Jony, Weiss, Matthew J, Wolfgang, Christopher L, Yamaue, Hiroki, Zeh, Herbert J, Zureikat, Amer H   +50 more
core   +2 more sources

Repeat hepatic resection versus percutaneous ablation for the treatment of recurrent hepatocellular carcinoma: meta-analysis [PDF]

, 2022
Bao‐Hong Yuan, Yankun Zhu, Xu-Ming Zou, Haodong Zhou, Ruhong Li, Jian‐Hong Zhong   +5 more
openalex   +1 more source

Multi‐Omics Integration for Advancing Glioma Precision Medicine

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Gliomas are among the most malignant and aggressive tumors of the central nervous system, characterized by the absence of early diagnostic markers, poor prognosis, and a lack of effective treatments. Advances in high‐throughput technologies have facilitated a refined molecular classification of gliomas, incorporating genetic features. However,
Maria Guarnaccia, Valentina La Cognata, Giulia Gentile, Giovanna Morello, Sebastiano Cavallaro   +4 more
wiley   +1 more source