Results 81 to 90 of about 1,768,776 (397)

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

The Art of Intraoperative Glioma Identification

Frontiers in Oncology, 2015
A major dilemma in brain tumor surgery is the identification of tumor boundaries to maximize tumor excision and minimize postoperative neurological damage.
Zoe Z Zhang, Lisa B.E. Shields, David eSun, Yi Ping eZhang, Matthew A Hunt, Christopher Brian Shields, Christopher Brian Shields   +6 more
doaj   +1 more source

The relationship between systemic inflammation and stoma formation following anterior resection for rectal cancer: a cross-sectional study [PDF]

, 2017
Introduction: There is evidence that temporary defunctioning stoma formation in patients undergoing anterior resection reduces the risk of anastomotic leakage.
Horgan, Paul G., Khor, Bo Y., McMillan, Donald C., McSorley, Stephen T.   +3 more
core   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

The Impact of Spinal Anesthesia and Use of Oxytocin on Fluid Absorption in Patients Undergoing Operative Hysteroscopy: Results from a Prospective Controlled Study

International Journal of Women's Health, 2020
Naser Al-Husban,1 Abdelkarim Aloweidi,2 Omar Ababneh2 1Obstetrics and Gynecology Department, School of Medicine, The University of Jordan, Amman, Jordan; 2Department of Anesthesia, School of Medicine, The University of Jordan, Amman, JordanCorrespondence:
Al-Husban N, Aloweidi A, Ababneh O
doaj  

Guiding Device for the Patellar Cut in Total Knee Arthroplasty: Design and Validation

Bioengineering, 2018
An incorrect cut of the patella (kneecap) during total knee arthroplasty, affects the thickness in different quadrants of the patella, leading to pain and poor function.
Erica L. Rex, Cinzia Gaudelli, Emmanuel M. Illical, John Person, Karen C. T. Arlt, Barry Wylant, Carolyn Anglin   +6 more
doaj   +1 more source

Operative technique for reconstruction of distal ulna after giant cell tumour resection

Acta Clinica Croatica, 2023
Giant cell tumour (GCT) is a rare, benign tumour, but it has a locally aggressive nature and a high rate of recurrence. A wide en-bloc resection of the distal part of the ulna, with or without stabilisation of the ulnar stump, is the recommended ...
Katarina Barbarić Starčević, Ivan Bohaček   +1 more
doaj   +1 more source

High thymidylate synthase gene expression predicts poor outcome after resection of hepatocellular carcinoma. [PDF]

, 2019
IntroductionPrognosis after resection of hepatocellular carcinoma (HCC) is highly variable. Compared to clinicopathologic factors, the use of molecular markers to predict outcome has not been well studied.
Antonia, Ricardo J, Bergsland, Emily K, Donner, David B, Hwang, Jimee, Lenz, Heinz-Josef, Lin, Meng Hsun, Nakakura, Eric K, Toriguchi, Kan, Venook, Alan P, Warren, Robert S, Zhang, Wu   +10 more
core  

BLM–DNA2–RPA–MRN and EXO1–BLM–RPA–MRN constitute two DNA end resection machineries for human DNA break repair [PDF]

, 2011
Repair of dsDNA breaks requires processing to produce 3′-terminated ssDNA. We biochemically reconstituted DNA end resection using purified human proteins: Bloom helicase (BLM); DNA2 helicase/nuclease; Exonuclease 1 (EXO1); the complex comprising MRE11 ...
Campbell, Judith L., Genschel, Jochen, Kinoshita, Eri, Kowalczykowski, Stephen C., Modrich, Paul, Nimonkar, Amitabh V., Polaczek, Piotr, Wyman, Claire   +7 more
core   +3 more sources

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren, Moana Busch, Pedro A. Ruiz, Ermanno Malagola, Valeria Baumeler, Federica Foti, Adelina Gross, Tobias Grütter, Hendrik Edel, Cordelia Schuler, Kristina Handler, Glenn De Lange, Isabelle C. Arnold, Cheryl de Vallière, Klaus Seuwen, Martin Hausmann, Gerhard Rogler   +16 more
wiley   +1 more source