Results 71 to 80 of about 152,940 (303)
Resemblance and Discrimination in Elections [PDF]
Discrimination affects hiring, mating and voting decisions. Whilst discrimination in elections mainly relates to gender or race, we introduce a novel source of discrimination: candidate resemblance.
Poupakis, Stavros +1 more
core +3 more sources
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
, 1977 The notion of resemblance has adopted many metaphorical senses and as a result has grown in language to become a very powerful and pregnant concept, a concept which deserves philosophical attention and clarification. Mere similarity in just any regard is
Thorne, Gary Wayne Alfred
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
RESEMBLANCE, EXEMPLIFICATION, AND ONTOLOGY [PDF]
American Philosophical Quarterly, 2018 Abstract According to the quantificational (neo-)Quinean model in meta-ontology, the question of ontology boils down to the question of whether a sortal property is exemplified. I address some complications that arise when we try to build a philosophical reconstruction of the link between individuals and kinds displayed in the ...
openaire +2 more sources
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Types and degrees of interpretive resemblance in translation
, 2001 This articles explores one of the types of interpretive resemblance found in translation, namely, resemblance between concepts. These are cases where the concept encoded involves a resemblance relation between its literal import and the meaning it ...
Rosales Sequeiros, Xosé
core
Parental Investment and Resemblance: Replications, Refinements, and Revisions
Evolutionary Psychology, 2007 Evolutionary theory predicts that men should be more concerned with issues of false paternity than women should be concerned with false maternity. In an earlier study ( Volk and Quinsey, 2002 ), we studied how infant cues of resemblance influenced adults'
Anthony A. Volk, Vernon L. Quinsey
doaj +1 more source
Frontiers in Psychology, 2016 Father-child facial resemblance is an important cue for men to evaluate paternity. Previous studies found that fathers’ perceptions of low facial resemblance with offspring lead to low confidence of paternity.
Yu eQuanlei +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source