Results 71 to 80 of about 19,131,340 (388)

Halogen-aromatic π interactions modulate inhibitor residence time

bioRxiv, 2018
Prolonged drug residence times may result in longer lasting drug efficacy, improved pharmacodynamic properties and “kinetic selectivity” over off-targets with fast drug dissociation rates.
C. Heroven, Victoria Georgi, Gaurav K. Ganotra, P. Brennan, Finn D. Wolfreys, R. Wade, A. Fernández-Montalván, A. Chaikuad, S. Knapp   +8 more
semanticscholar   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Complete Evaluation of Cell Mixing and Hydrodynamic Performance of Thin-Layer Cascade Reactor

Applied Sciences, 2020
Microalgae are a great source of food and supplements as well as a potential source for the production of biofuels. However, the operational cost must be reduced to allow viable productions of bulk chemicals such as biofuels from microalgae. One approach
Shehnaz Akhtar, Haider Ali, Cheol Woo Park   +2 more
doaj   +1 more source

Residence time distributions in laminated microstructured plate reactors [PDF]

, 2009
This paper was presented at the 2nd Micro and Nano Flows Conference (MNF2009), which was held at Brunel University, West London, UK. The conference was organised by Brunel University and supported by the Institution of Mechanical Engineers, IPEM, the ...
2nd Micro and Nano Flows Conference (MNF2009), Barrass, S, Bi, S, Cantu-Perez, A, Gavriilidis, A, Wood, M   +5 more
core  

Residence time statistics for $N$ blinking quantum dots and other stochastic processes

, 2011
We present a study of residence time statistics for $N$ blinking quantum dots. With numerical simulations and exact calculations we show sharp transitions for a critical number of dots.
E. Barkai, G. Margolin, S. Burov, S. N. Majumdar, S. N. Majumdar   +4 more
core   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Development and Use of a Residence Time Distribution (RTD) Model Control Strategy for a Continuous Manufacturing Drug Product Pharmaceutical Process [PDF]

, 2022
Samantha Hurley, Anthony Tantuccio, M. Sebastian Escotet‐Espinoza, Matthew Flamm, Matthew Metzger   +4 more
openalex   +1 more source

On the joint residence time of N independent two-dimensional Brownian motions

, 2003
We study the behavior of several joint residence times of N independent Brownian particles in a disc of radius $R$ in two dimensions. We consider: (i) the time T_N(t) spent by all N particles simultaneously in the disc within the time interval [0,t]; (ii)
Agmon N, Bar-Haim A, Berezhkovskii A M, Blumen A, Boguñá M, Bénichou O, Darling D A, de Gennes P G, Dräger J, Eigen M, Feller W, G Oshanin, Hughes B H, J Klafter, Kallianpur G, Larralde H, M Coppey, M Moreau, O B nichou, Weiss G H, Weiss G H, Yuste B, Yuste S B, Zumofen G   +23 more
core   +3 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Euphotic Zone Residence Time of Antarctic Bottom Water

Geophysical Research Letters
Antarctic Bottom Water (AABW) transports surface nutrients deep into the ocean, sequestering them for centuries. Enhancing its biological carbon fixation could augment carbon sinks and reduce atmospheric CO2.
Yinghuan Xie, Paul Spence, Stuart Corney, Veronica Tamsitt, Hannah R. S. Dawson, Christina Schmidt, Lennart T. Bach   +6 more
doaj   +1 more source