Results 141 to 150 of about 85,107 (267)
Systematic Multi‐Level Analyses Decode the Arthritis‐Neurodegeneration Axis With In Vivo Validation
Arthritis and neurodegeneration are usually studied as separate disorders, but this study connects them through population evidence, genetic inference, transcriptomic mapping, and mouse models. It highlights RNF40 as a context‐dependent joint‐brain candidate, induced in inflammatory joints yet functionally linked to dopamine‐neuron vulnerability ...
Jinwen Wang +7 more
wiley +1 more source
Incorporating coaching in the moment and coaching over time to support entrustable professional activity-based assessment in pathology residency training. [PDF]
Schiffhauer LM +11 more
europepmc +1 more source
A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu +17 more
wiley +1 more source
Gender and Racial Discrimination During Residency Training: Scoping Review. [PDF]
John I, Dennett L, Nguyen J, Rashid M.
europepmc +1 more source
High glucose is linked to reduced succinate dehydrogenase activity in CD14+ monocytes, accompanied by succinate accumulation and extracellular release. Extracellular succinate exacerbates mitochondrial ROS production and mtDNA release in CD4+ T cells. Cytosolic mtDNA then activates Z‐DNA binding protein 1 (ZBP1) and engages ZBP1‐associated inflammatory
Shuai Zhao +11 more
wiley +1 more source
Surgical skills laboratories in plastic surgery residency training: A national survey of current practices and barriers. [PDF]
Falade I +5 more
europepmc +1 more source
Residency training in colposcopy
openaire +2 more sources
TSTScope is an interpretable AI framework that integrates single‐cell transcriptomes with TCR information through curated gene‐program constraints. By linking receptor context to functional T cell states, it reveals response‐associated tumor‐specific T cell programs in lung cancer immunotherapy cohorts and defines an MPR score associated with ...
Shiwei Cao +8 more
wiley +1 more source
A Simulation-Integrated Approach to Advancing Pediatric Emergency Preparedness in Morning Report Within Residency Training. [PDF]
Wong KU, Sule H.
europepmc +1 more source

