Results 41 to 50 of about 10,148 (283)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Overview of High-Power and Wideband Radar Technology Development at MIT Lincoln Laboratory

open access: yesRemote Sensing
This paper summarizes over 60 years of radar system development at MIT Lincoln Laboratory, from early research on satellite tracking and planetary radar to the present ability to perform the centimeter-resolution imaging of resident space objects and ...
Michael MacDonald   +2 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Characterisation of resident space objects using multistatic interferometric inverse synthetic aperture radar imaging

open access: yesIET Radar, Sonar & Navigation
This paper illustrates an interferometric inverse synthetic aperture radar based on three‐dimensional imaging and rotational velocity estimation from a multistatic setup with three ground‐based radars with non‐orthogonal baselines.
Manjunath Thindlu Rudrappa   +2 more
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Uncertainty Quantification for Space Situational Awareness and Traffic Management

open access: yesSensors, 2019
This paper presents a sensor-orientated approach to on-orbit position uncertainty generation and quantification for both ground-based and space-based surveillance applications.
Samuel Hilton   +5 more
doaj   +1 more source

Observational Evidence of a Centi-parsec Supermassive Black Hole Binary Existing in the Nearby Galaxy M81

open access: yesThe Astrophysical Journal, 2023
Studying a centi-parsec supermassive black hole binary (SMBHB) would allow us to explore a new parameter space in active galactic nuclei, and these objects are also potential sources of gravitational waves.
Wu Jiang   +8 more
doaj   +1 more source

Instance Segmentation for Feature Recognition on Noncooperative Resident Space Objects

open access: yesJournal of Spacecraft and Rockets, 2022
Active debris removal and unmanned on-orbit servicing missions have gained interest in the last few years, along with the possibility to perform them through the use of an autonomous chasing spacecraft. In this work, new resources are proposed to aid the implementation of guidance, navigation, and control algorithms for satellites devoted to the ...
Niccolò Faraco   +2 more
openaire   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Operational Angular Track Reconstruction in Space Surveillance Radars through an Adaptive Beamforming Approach

open access: yesAerospace
In the last few years, many space surveillance initiatives have started to consider the problem represented by resident space object overpopulation. In particular, the European Space Surveillance and Tracking (EUSST) consortium is in charge of providing ...
Marco Felice Montaruli   +4 more
doaj   +1 more source

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