Results 61 to 70 of about 524,865 (248)

Gorham-Stout disease presenting with dyspnea and bone pain in a 9-year-old girl

Radiology Case Reports, 2015
Gorham-Stout (GS) disease is a rare bone disorder of unknown etiology that is characterized by local proliferation of small vascular or lymphatic channels, resulting in progressive osteolysis and bone resorption.
Eric A. Davalos, MD, Nishant M. Gandhi, MD, David Barank, MD, Rajeev K. Varma, MD   +3 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Gallbladder perforation in a patient undergoing PCNL: Case report and literature review

Urology Case Reports
Percutaneous nephrolithotripsy (PCNL) is an effective therapeutic approach in cases of lithiasis, which is prone to complications. In this report we present a case of a 52-year-old female patient with recurrent episodes of lithiasis and, after PCNL ...
Alessandro Vengjer, André Segura da Motta, Matheus Campos Alves Corrêa, Julia Corazza Nitta Yoshisaki, Marcelo Ribeiro de Azevedo, Olavo Napoleão de Araújo Neto   +5 more
doaj   +1 more source

Adult Reye-like syndrome associated with serologic evidence of acute parvovirus B19 infection

Brazilian Journal of Infectious Diseases, 2011
Reye's syndrome is an infrequently diagnosed medical condition affecting mainly children. The etiology, epidemiology and natural history of Reye's syndrome have been cloudily written in footnotes of medical books and exotic papers since the initial ...
Paulo Sérgio Gonçalves da Costa, PhD, Geyza Machado Ribeiro, Thiago Cardoso Vale, Thaís Gomes Casali, Flávio José Barbosa Leite   +4 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Warthin like papillary carcinoma - A rare variant of papillary carcinoma thyroid

Human Pathology: Case Reports, 2018
Warthin-like variant is one of the histologic variants of papillary thyroid cancer that has rarely been reported. It is classically seen in females over the age of 50 years.
Mir Wajahat, Tazeen Jeelani, Kanika Gupta, Nusrat Bashir   +3 more
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Success rate of nasogastric tube insertion in anesthetized, intubated, adult patients: A comparison between endotracheal tube cuff inflated and deflated states

Asian Journal of Medical Sciences
Background: Although proper placement of nasogastric tube (NGT) is a simple procedure, it can turn into a tedious task in an anesthetized intubated patient due to the absence of propulsive movement of swallowing. Different techniques of NGT placement are
Nazimuddin Paik , Soma Chakraborty , Sangita Mandal , Sarfraaz Rahman , Sayantan Modak , Arpan Chakraborty , Mohanchandra Mandal   +6 more
doaj   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source