Results 71 to 80 of about 1,134,808 (284)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Prospecting the protein design landscape

open access: yesFEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona   +4 more
wiley   +1 more source

Gorham-Stout disease presenting with dyspnea and bone pain in a 9-year-old girl

open access: yesRadiology Case Reports, 2015
Gorham-Stout (GS) disease is a rare bone disorder of unknown etiology that is characterized by local proliferation of small vascular or lymphatic channels, resulting in progressive osteolysis and bone resorption.
Eric A. Davalos, MD   +3 more
doaj   +1 more source

Permanent resident [PDF]

open access: yesMedical Education Online, 2016
The training of physicians in the past century was based primarily on responsibility and the chain-of-command. Those with the bulk of that responsibility in the fields of pediatrics and internal medicine were residents. Residents trained the medical students and supervised them carefully in caring for patients.
openaire   +3 more sources

Keeping partners together: algorithmic results for the hospitals/residents problem with couples [PDF]

open access: yes, 2009
The Hospitals/Residents problem with Couples (HRC) is a generalisation of the classical Hospitals/Residents problem (HR) that is important in practical applications because it models the case where couples submit joint preference lists over pairs of ...
McDermid, E.J.   +3 more
core   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

open access: yesFEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Cochlear implants: our experience and literature review

open access: yesInternational Archives of Otorhinolaryngology, 2012
Summary Introduction: Cochlear Implants are important for individuals with severe to profound bilateral sensorineural hearing loss. Objective: Evaluate the experience of cochlear implant center of Otorhinolaryngology through the
Mariane Barreto Brandão Martins   +5 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

open access: yesFEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise   +5 more
wiley   +1 more source

Success rate of nasogastric tube insertion in anesthetized, intubated, adult patients: A comparison between endotracheal tube cuff inflated and deflated states

open access: yesAsian Journal of Medical Sciences
Background: Although proper placement of nasogastric tube (NGT) is a simple procedure, it can turn into a tedious task in an anesthetized intubated patient due to the absence of propulsive movement of swallowing. Different techniques of NGT placement are
Nazimuddin Paik   +6 more
doaj   +1 more source

Prevalence of Malocclusion Among Medical Students in Institute of Medicine, Nepal: A Preliminary Report

open access: yesOrthodontic Journal of Nepal, 2011
Introduction: Malocclusion is a malrelationship between the arches in any of the planes or in which there are anomalies in tooth position beyond the normal limits.
Basanta K Shrestha   +3 more
doaj   +1 more source

Home - About - Disclaimer - Privacy