Results 61 to 70 of about 1,134,808 (284)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Using Literature Review to Inform an Anti-Oppressive Approach to Community Safety

Engaged Scholar Journal
Literature review is a common piece of any scholarly research, but it is rare for it to be squarely at the centre of a community-based project.
Julie Chamberlain, Stacy Cardigan Smith, Dagen Perrott   +2 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Peeling Skin Syndrome - Relato de Caso

Revista da Sociedade Portuguesa de Dermatologia e Venereologia, 2016
Peeling skin syndrome (PSS) é uma genodermatose rara, de herança autossômica recessiva causada por mutações nos genes CDSN, TGM5 ou CHTS8 dependendo do tipo da doença. É caracterizada por descamação superficial da pele, localizada (acral) ou generalizada,
Priscila Silva Correia, Gabriela Higino de Souza, Thais Marques Feitosa Mendes Siqueira, Fernando Aguiar Luz, Daniel Lago Obadia, Luna Azulay-Abulafia   +5 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Secondary Amyloidosis with Amyloid Goitre Presenting as a Multinodular Goitre

Endocrinology Research and Practice, 2007
Amyloid goitre is a rare entity defined by the presence of amyloid within the thyroid gland in such quantities as to produce clinically apparent enlargement of the gland. It affects the thyroid in a bilateral and diffuse manner.
Kajal Kıran Dhingra, Mandal Shramana, Nita Khurana, Arun Kumar Kakkar   +3 more
doaj   +2 more sources

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Dermatite Infeciosa Associada a Infeção por HTLV-1 no Adulto: Difícil Diagnóstico e Importante Manejo Clínico

Revista da Sociedade Portuguesa de Dermatologia e Venereologia, 2017
A dermatite infeciosa é uma dermatite grave, crónica e recidivante associada ao vírus linfotrópico de células T humano tipo 1 (HTLV-1). Embora a maioria dos casos descritos tenha início na infância, casos de dermatite infeciosa em adultos tem sido ...
Priscila Silva Correia, Fernanda Cabral, Gabriela Higino de Souza, Miguel Barrella Neto, Daniel Lago Abadia, Igor Brum Cursi   +5 more
doaj   +1 more source