Results 111 to 120 of about 1,389,226 (316)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Modeling and Optimal Design of Machining-Induced Residual Stresses in Aluminium Alloys Using a Fast Hierarchical Multiobjective Optimization Algorithm [PDF]

, 2011
The residual stresses induced during shaping and machining play an important role in determining the integrity and durability of metal components. An important issue of producing safety critical components is to find the machining parameters that create ...
Yates, John R., Greene, Richard J., Boumaiza, Soufiene, Mahfouf, Mahdi, Zhang, Qian, de Leon, Luis, Richard J. Greene, Christophe Pinna, John R. Yates, Pinna, Christophe, Soufiene Boumaiza, George Panoutsos, Qian Zhang, Panoutsos, George, Mahdi Mahfouf, Luis de Leon   +15 more
core   +1 more source

Fault Detection of Flow Control Valves Using Online LightGBM and STL Decomposition

Actuators
In the process industrial systems, flow control valves are deemed vital components that ensure the system’s safe operation. Hence, detecting faults in control valves is of significant importance.
Shaodong Liu, Tao Zhao, Dengfeng Zhang
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Determination of Residual Stress Distributions in Autofrettaged Thick Cylinders [PDF]

, 2008
High pressure vessels such as gun barrels are autofrettaged in order to increase their operating pressure and fatigue life. Autofrettage causes plastic expansion of the inner section of the cylinder – setting up residual compressive stresses at the ...
Gibson, Michael C.
core  

Analysis of Residual Stress in Stres Harps of Grey Iron by Experiment and Simulation

, 2014
Stress harps with bars of different size were used to study residual stresses due to different cooling rate during casting of a grey iron. Finite element (FE) simulations were performed to predict residual stresses from the casting process and the effect
Johansson, Sten,, Peng, Ru,, Ahmad, Maqsood,, Bäckström, Daniel,, Davydov, Vadim,, Lundberg, Mattias,, Schmidt, Pål,, Vuoristo, Taina,   +7 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

X-ray analysis of residual stress gradients and textures in thin coatings

, 2022
S.663-671The increasing interest in coatings is understandable for their importance in microelectronic technology and in surface treatments of various materials to get good wear and corrosion resistance.
Kämpfe, B., Auerswald, E., Michel, B., Schubert, A.   +3 more
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source