Results 131 to 140 of about 710,769 (238)

Environmental and public health outcomes following the Fundão dam collapse (Mariana, Brazil): a retrospective ecological study of drinking water quality and cancer mortality. [PDF]

Lancet Reg Health Am
Panis C, Ponmattam J, Pires de Paula Filho AR, Paz RG, Gaboardi SC, Wendt GW, Castro MC.   +6 more
europepmc   +1 more source

Breakthrough Design of Highly Potent Antivirals Against Wild‐Type HIV‐1 and Lenacapavir‐Resistant M66I Variant

Angewandte Chemie, EarlyView.
Lenacapavir, the first‐in‐class drug targeting HIV‐1 capsid, is a breakthrough drug in HIV‐1 treatment and prophylaxis. However, a single M66I mutation confers complete viral resistance to lenacapavir. We report herein the design and synthesis of innovative R2 analogs demonstrating low nM potency against HIV‐1 M66I and excellent pharmacokinetics in ...
Nicolas Jamey, D. M. Nirosh Udayanga, Huanchun Zhang, Roshan Katekar, Wei Xie, Shreya M. Ravichandran, Xinyong Cai, Zachary C. Lorson, William M. McFadden, Won Hee Ryu, Jiashu Xie, Karen A. Kirby, Stefan G. Sarafianos, Zhengqiang Wang   +13 more
wiley   +1 more source

An Alkali Amide Approach to Triphosphabenzenes

Angewandte Chemie, EarlyView.
Alkali metal amides offer a simple route to phosphorus aromatics. LiNMe2 catalyzes [2+2+2] cyclotrimerization of a phosphaalkyne, while tetrahydrofuran (THF) stabilizes a λ4‐triphosphabenzene anion intermediate. Using KN(SiMe3)2 switches reactivity to arene C(sp3)─H activation, giving benzylated λ4‐triphosphabenzenes and rare λ5‐triphosphabenzenes ...
Owen J. Jones, Andrew D. Bond, Ruth L. Webster   +2 more
wiley   +2 more sources

Occurrence modes of gold and relevant analytical methodologies. [PDF]

RSC Adv
Li D, Zhang X, Zhang L, Fang P, Feng L, Wang J, Zhang Z.   +6 more
europepmc   +1 more source

Efficient cyanide degradation by Aspergillus welwitschiae LOT1 isolated from industrial waste. [PDF]

Int Microbiol
Lawal OT, Osunpidan ST, Sanni DM.
europepmc   +1 more source

The Application of Polyrotaxane Cellulose Composite Materials in Quasi-Solid Electrolytes. [PDF]

Bioengineering (Basel)
Wang T, Chen W, Liu Y, Ren K, Liang J, Kong J.   +5 more
europepmc   +1 more source

Expanding Yarrowia lipolytica's metabolic potential for detoxification of cyanogenic glycosides in edible plants. [PDF]

Commun Biol
Azi F, Li Z, Xu P.
europepmc   +1 more source

Cobalt-Catalyzed γ‑C-H Functionalization of Alcohols via Olefin-Tethered Radical Relay. [PDF]

JACS Au
Dam P, Amarasinghe KN, Wang C, Bokareva OS, Azofra LM, El-Sepelgy O.   +5 more
europepmc   +1 more source

In-situ enhancement of autotrophic nitrogen removal in coking wastewater using staged diatomite and pyrite strategy. [PDF]

Commun Eng
Ren Z, Ma J, Ding P, Chu H, Zhou X, Zhang Y.   +5 more
europepmc   +1 more source

Difluoromethylenation of Alkynes: Streamlined Access to Allyl Difluorides

Angewandte Chemie, EarlyView.
Stabilizing primary oxocarbenium in HF/pyridine unlocks a direct alkyne difluoromethylenation – an efficient route to synthetically‐relevant allyl difluorides in a single step. ABSTRACT A direct difluoromethylenation of alkynes has been developed using HF/pyridine as a dual acidic and fluorinating medium. The reaction proceeds via in situ generation of
Fabien Naullet, Sourav Mondal, Frédéric Guégan, Bastien Michelet, Sébastien Thibaudeau   +4 more
wiley   +1 more source