Results 71 to 80 of about 763,518 (232)

Construction of fractional power series solutions to fractional stiff system using residual functions algorithm

Advances in Difference Equations, 2019
A powerful analytical approach, namely the fractional residual power series method (FRPS), is applied successfully in this work to solving a class of fractional stiff systems.
Asad Freihet, Shatha Hasan, Mohammed Al-Smadi, Mohamed Gaith, Shaher Momani   +4 more
doaj   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Solutions of Stiff Systems of Ordinary Differential Equations Using Residual Power Series Method

Journal of Mathematics, 2022
The stiff differential equations occur in almost every field of science. These systems encounter in mathematical biology, chemical reactions and diffusion process, electrical circuits, meteorology, mechanics, and vibrations. Analyzing and predicting such
Mubashir Qayyum, Qursam Fatima
doaj   +1 more source

Adapting semi-analytical treatments to the time-fractional derivative Gardner and Cahn-Hilliard equations

Alexandria Engineering Journal
This paper used the flexible and efficient least squares residual power series method (LSRPSM) to solve the time-fractional derivative Cahn-Hilliard and Gardener equations. The LSRPSM combines the residual power series method (RPSM) and the least squares
A. Hassan, A.A.M. Arafa, S.Z. Rida, M.A. Dagher, H.M. El Sherbiny   +4 more
doaj   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

On the robustness of cointegration tests when series are fractionally integrated [PDF]

, 1996
This paper shows, analytically and numerically, the effects of a misspecification in the degree of integration on testing for cointegration. Johansen LR tests tend to find too much spurious cointegration while the Engle-Granger test shows a more robust ...
Gonzalo, Jesús, Lee, Tae-Hwy
core   +1 more source

A Systematic All-Orders Method to Eliminate Renormalization-Scale and Scheme Ambiguities in PQCD

, 2013
We introduce a generalization of the conventional renormalization schemes used in dimensional regularization, which illuminates the renormalization scheme and scale ambiguities of pQCD predictions, exposes the general pattern of nonconformal {\beta_i ...
/CP3-Origins, Odense /SLAC, /SLAC, Brodsky, Stanley J., Mojaza, Matin, U., /Chongqing, Wu, Xing-Gang   +5 more
core   +2 more sources

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Approximate Analytical Solutions for Strongly Coupled Systems of Singularly Perturbed Convection–Diffusion Problems

Mathematics
This work presents a reliable algorithm to obtain approximate analytical solutions for a strongly coupled system of singularly perturbed convection–diffusion problems, which exhibit a boundary layer at one end. The proposed method involves constructing a
Essam R. El-Zahar, Ghaliah F. Al-Boqami, Haifa S. Al-Juaydi   +2 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source