Results 111 to 120 of about 408,004 (261)
New Field Testing Procedure For Measuring Residual Stress in Plain Concrete Pavements and Structures
, 2010 Residual stresses in rigid pavements diminish a pavement's ability to sustain its designed load. When capacity is reduced by residual stress, a pavement is vulnerable to premature failure necessitating costly repairs or replacement.
Castaneda, Daniel I.
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Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Numerical Exploration of Residual Stress Mechanisms in Rock
Residual stresses exist in materials isolated from applied loading and are typically omitted from designs and studies. This research investigates potential implications for residual stress in rock mechanics and rock engineering through the use of 2D ...
Trzop, Maxzender
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Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Measurement of residual stresses in the turbine housings of turbochargers
, 2014 Emission regulations in Europe are extremely stringent and only turbocharged and charged-air-cooled engines are able to comply with current requirements.
Kiumars, Shogi +2 more
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Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Effect of Preheating on the Residual Stress in Type 304 Stainless Steel Weldment
, 2012 [[abstract]]This study aimed at the investigation of the effect of preheating on the residual stress and metallurgical properties of weldment. In this study, an autogenous gas tungsten arc welding was used on type 304 stainless steel. During welding, the
Lin, Yi- Cheng; Lee, K. H.
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