Results 121 to 130 of about 654,490 (307)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
ChemEngineeringAluminum is the most used non–ferrous metal. It can be recycled saving several natural resources, but generates large amounts of residues with a complex composition—still containing a valuable amount of aluminum, although also including contaminant ...
Alejandro Jiménez +4 more
doaj +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Cross-linking of Polystyrene by Friedel–Crafts Chemistry to Improve Thermal Stability [PDF]
, 1999 Copolymers which contain either alcohol or chloride functionalized polystyrene units have been prepared and they participate in Friedel–Crafts chemistry to give cross-linked polymers by the evolution of either hydrogen chloride or water.
Jiang, David D. +3 more
core +1 more source
The chemistry of smoke suppression in polyurethane foams using thermogravimetry‐infrared residue analysis [PDF]
, 1993 Geoffrey M. Anthony
openalex +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
β-Blockers in the Environment: Challenges in Understanding Their Persistence and Ecological Impact
Moleculesβ-blockers are among the most highly consumed cardiovascular drugs worldwide, resulting in their classification as persistent and bioactive pharmaceutical pollutants.
Anna Dzionek
doaj +1 more source
Thermal Decomposition of Cross-linked Polybutadiene and its Copolymers [PDF]
, 1999 Polybutadiene and two copolymers containing butadiene and styrene have been cross-linked by thermal processes, by the use of initiators in solution, and by intimately mixing an initiator with the polymer and then heating this blend.
Jiang, David D. +3 more
core +1 more source