Nature Communications, 2017 Current strategies for producing antibody-drug conjugates often rely on inefficient conjugation chemistry or on generating mutations in the antibody sequence.
Alex R. Nanna +8 more
doaj +1 more source
Effect of charged lipids on the ionization behavior of glutamic acid containing transmembrane helices [PDF]
, 2020 Transmembrane proteins make up critical components of living cells. Protein function can be greatly impacted by the charged state of its respective components, the side chains of amino acid residues.
Nunn, Brooke
core +2 more sources
Química Nova, 2008 The discussion among teachers, students, and technicians about the destination of residues from chemistry laboratories led to a research project whose results were incorporated into a course in its daily practices.
Regina Felisberto +6 more
doaj +1 more source
Influence of the isomeric composition of the acceptor on the performance of organic bulk heterojunction P3HT:bis-PCBM solar cells [PDF]
, 2012 We synthesized three isomeric subpopulations of bisadduct analogues of [6,6]-phenyl-C61-butyric acid methyl ester (bis-PCBM) via tether-directed control.
Blom, Paul W.M., +3 more
core +2 more sources
Functional differences of iodinated obestatin peptides: in vitro metabolic stability profile [PDF]
, 2010 Peptides are small polymers of 50 amino acids, situated between organic molecules and proteins. Most peptides perform a biochemical-physical function and are therefore considered as potential drugs.
De Spiegeleer, Bart +2 more
core +1 more source
Allo-network drugs: Extension of the allosteric drug concept to protein-protein interaction and signaling networks [PDF]
, 2013 Allosteric drugs are usually more specific and have fewer side effects than orthosteric drugs targeting the same protein. Here, we overview the current knowledge on allosteric signal transmission from the network point of view, and show that most ...
Csermely, Péter +2 more
core +2 more sources
Per- and Polyfluoroalkyl Substance Levels in Commercial and Home-Produced Eggs in Croatia
FoodsThe aim of this study was to measure per- and polyfluoroalkyl substance (PFAS) levels in eggs collected in Croatia and to identify differences between commercially produced eggs (cage, barn, and organic) and home-produced eggs (HPE).
Nina Bilandžić +10 more
doaj +1 more source
Molecules, 2013 A series of 4β-triazole-linked glucose podophyllotoxin conjugates have been designed and synthesized by employing a click chemistry approach. All the compounds were evaluated for their anticancer activity against a panel of five human cancer cell lines ...
Cheng-Ting Zi +7 more
doaj +1 more source
Peripherally-metallated porphyrins: meso-n1-porphyrinyl-platinum(II) complexes of 5,15-diaryl- and 5,10,15-triarylporphyrins [PDF]
, 2002 Attempted metathesis reactions of peripherally-metallated meso-η1-porphyrinylplatinum(II) complexes such as trans-[PtBr(NiDPP)(PPh3)2] (H2DPP = 5,15-diphenylporphyrin) with organolithium reagents fail due to competitive addition at the porphyrin ring ...
Arnold, Dennis +2 more
core +2 more sources
Novel polymer coupling chemistry based upon latent cysteine-like residues and thiazolidine chemistry
Polymer Chemistry, 2010 Chain end functional polymers were prepared via reversible addition–fragmentation transfer (RAFT) polymerization techniques that were further chain extended with acrylonitrile. Under reducing conditions, latent cysteine-like residues were exposed at the chain ends.
Carlson, Jospeh S. +3 more
openaire +3 more sources