Results 41 to 50 of about 663,482 (304)

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Pharmaceuticals in Food and Water: Monitoring, Analytical Methods of Detection and Quantification, and Removal Strategies

Separations
Pharmaceuticals, classified as emerging pollutants, are extensively applied in both human and veterinary medicine to treat various diseases. Their widespread application has led to their occurrence in water, soil, sediments, and living organisms. Even at
Ines Varga, Nina Bilandžić, Silvia Morović, Krešimir Košutić   +3 more
doaj   +1 more source

Synthesis and Anticancer Activity of Glucosylated Podophyllotoxin Derivatives Linked via 4β-Triazole Rings

Molecules, 2013
A series of 4β-triazole-linked glucose podophyllotoxin conjugates have been designed and synthesized by employing a click chemistry approach. All the compounds were evaluated for their anticancer activity against a panel of five human cancer cell lines ...
Cheng-Ting Zi, Feng-Qing Xu, Gen-Tao Li, Yan Li, Zhong-Tao Ding, Jun Zhou, Zi-Hua Jiang, Jiang-Miao Hu   +7 more
doaj   +1 more source

Probing the Human Estrogen Receptor-α Binding Requirements for Phenolic Mono- and Di-Hydroxyl Compounds: A Combined Synthesis, Binding and Docking Study [PDF]

, 2014
Various estrogen analogs were synthesized and tested for binding to human ERα using a fluorescence polarization displacement assay. Binding affinity and orientation were also predicted using docking calculations.
Donaldson, William A., Gone, Jayapal Reddy, He, Zhengjie, Herrild, Christian, Lukesh, Julie, McCullough, Christopher, Neumann, Terrence S., Pandey, Rajesh K., Sem, Daniel S.   +8 more
core   +1 more source

Reactive trityl derivatives: stabilised carbocation mass-tags for life sciences applications [PDF]

, 2008
The rational design of novel triarylmethyl (trityl)-based mass tags (MT) for mass-spectrometric (MS) applications is described. We propose a "pKR+ rule" to correlate the stability of trityl carbocations with their MS performance: trityls with higher pKR+
Astakhova, Irina Kira, Astakhova, Irina V., Bernad, Pablo L., Khan, Safraz, Korshun, Vladimir A., Malakhov, Andrei D., Patel, Kaajal, Prokhorenko, Igor A., Shahgholi, Mona, Shchepinov, Mikhail S., Shmanai, Vadim V., Skorobogatyi, Mikhail V., Southern, Edwin M., Stepanova, Irina A., Ustinov, Alexey V.   +14 more
core   +2 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Single phase extraction method for determination of dithianon residues in fruits and vegetables using LC ESI (-) MS/MS

Scientific Reports
Dithianon is a non-systemic fungicide, applied in some agricultural products. Dithianon residues in food cause health problems for humans so it is recommended to be analyzed in fruits and vegetables.
Esmail Elsayed Aboshanab, Mahmoud Hamdy Abdelwahed, Sanaa A. M. El-Sawi, Mostafa M. Emara, Ahmed A. Omran   +4 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Mineral Concentrations in Different Types of Honey Originating from Three Regions of Continental Croatia

Foods
Honey has been recognized as a reliable indicator of environmental quality because of honeybees’ intense foraging activity, which brings them into contact with many persistent organic pollutants around the hive. In this study, four types of honey (meadow,
Ivana Tlak Gajger, Damir Pavliček, Višnja Oreščanin, Ivana Varenina, Marija Sedak, Nina Bilandžić   +5 more
doaj   +1 more source

Binding mode analyses of NAP derivatives as mu opioid receptor selective ligands through docking studies and molecular dynamics simulation [PDF]

, 2017
Mu opioid receptor selective antagonists are highly desirable because of their utility as pharmacological probes for receptor characterization and functional studies.
Wang, Huiqun, Zaidi, Saheem A., Zhang, Yan   +2 more
core   +2 more sources