Results 31 to 40 of about 1,091,714 (269)

Forecasting residue–residue contact prediction accuracy [PDF]

Bioinformatics, 2017
Abstract Motivation Apart from meta-predictors, most of today's methods for residue–residue contact prediction are based entirely on Direct Coupling Analysis (DCA) of correlated mutations in multiple sequence alignments (MSAs).
Wozniak, P.P., Konopka, B.M., Xu, J, Vriend, G., Vriend, G., Kotulska, M.   +5 more
openaire   +3 more sources

Advance in strategies to build efficient vaccines against tuberculosis

Frontiers in Veterinary Science, 2022
Tuberculosis is a chronic consumptive infectious disease, which can cause great damage to human and animal health all over the world. The emergence of multi-drug resistant strains, the unstable protective effect of Bacillus Calmette-Guérin (BCG) vaccine ...
Wei Qu, Wei Qu, Yinhui Guo, Yan Xu, Jie Zhang, Jie Zhang, Zongchao Wang, Chaoyue Ding, Yuanhu Pan, Yuanhu Pan   +9 more
doaj   +1 more source

Highly Sensitive Magnetic-Nanoparticle-Based Immunochromatography Assay for Rapid Detection of Amantadine in Chicken and Eggs

Biosensors, 2023
Amantadine (AMD) is an antiviral drug that is prohibited for use in livestock and poultry. In this study, carboxyl-modified magnetic nanoparticles (MNPs) were synthesized using the solvothermal method in one step with harmless and inexpensive regents ...
Huaming Li, Yanrong Lu, Linwei Zhang, Liangni Qin, Hao Wen, Xiaohui Fan, Dapeng Peng   +6 more
doaj   +1 more source

Antimicrobial resistance, virulence defects, and evolutionary dynamics of multidrug-resistant Klebsiella pneumoniae from human and animal hosts in Central China

Microbiology Spectrum
The global dissemination of multidrug-resistant Klebsiella pneumoniae (MDR-KP) poses a critical One Health challenge. This study investigated the antimicrobial resistance (AMR) profiles, virulence determinants, and zoonotic transmission risks of K ...
Wen Sun, Xiaoman Zhu, Xiaomin Pang, Xiangyun Wu, Qian Guo, Linshen Li, Baojing Dou, Yulian Wang   +7 more
doaj   +1 more source

Pharmacokinetic and Pharmacodynamic Drug–Drug Interactions: Research Methods and Applications

Metabolites, 2023
Because of the high research and development cost of new drugs, the long development process of new drugs, and the high failure rate at later stages, combining past drugs has gradually become a more economical and attractive alternative.
Lei Sun, Kun Mi, Yixuan Hou, Tianyi Hui, Lan Zhang, Yanfei Tao, Zhenli Liu, Lingli Huang   +7 more
doaj   +1 more source

Analysis of the stability and affinity of BlaR-CTD protein to β-lactam antibiotics based on docking and mutagenesis studies

Journal of Biological Engineering, 2019
Owing to the thermal instability and low affinity of BlaR-CTD to some β-lactams, the receptor assay based on BlaR-CTD is limited in the detection of abundant variety of drugs and the result is often unstable.
Jianan Ning, Saeed Ahmed, Guyue Cheng, Ting Chen, Yulian Wang, Dapeng Peng, Zonghui Yuan   +6 more
doaj   +1 more source

Study on the Metabolic Transformation Rule of Enrofloxacin Combined with Tilmicosin in Laying Hens

Metabolites, 2023
There is often abuse of drugs in livestock and poultry production, and the improper use of drugs leads to the existence of a low level of residues in eggs, which is a potential threat to human safety.
Jingchao Guo, Liyun Zhang, Yongxia Zhao, Awais Ihsan, Xu Wang, Yanfei Tao   +5 more
doaj   +1 more source

Preparation, characterization and pharmacokinetics of cyadox nanosuspension

Scientific Reports, 2017
An increase in number of newly developed synthetic drugs displays bioavailability constraints because of poor water solubility. Nanosuspensions formulation may help to overwhelm these problems by increasing dissolution velocity and saturation solubility.
Adeel Sattar, Dongmei Chen, Lishun Jiang, Yuanhu Pan, Yanfei Tao, Lingli Huang, Zhenli Liu, Shuyu Xie, Zonghui Yuan   +8 more
doaj   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Preparation of Aditoprim Injection against Streptococcus suis in Pigs and a Dose Regimen Based on Pharmacokinetic-Pharmacodynamic Modeling

Pharmaceutics, 2022
In order to effectively treat the infection of Streptococcus suis and reduce the emergence of drug-resistant bacteria, an aditoprim (ADP) injection was developed in this study.
Wei Qu, Mengxiao Dong, Yuanhu Pan, Shuyu Xie, Zonghui Yuan, Lingli Huang   +5 more
doaj   +1 more source