Results 61 to 70 of about 2,143,871 (297)

Application of Semi-Mechanistic Pharmacokinetic and Pharmacodynamic Model in Antimicrobial Resistance

Pharmaceutics, 2022
Antimicrobial resistance is a major public health issue. The pharmacokinetic/pharmacodynamic (PK/PD) model is an essential tool to optimize dosage regimens and alleviate the emergence of resistance.
Kun Mi, Kaixiang Zhou, Lei Sun, Yixuan Hou, Wenjin Ma, Xiangyue Xu, Meixia Huo, Zhenli Liu, Lingli Huang   +8 more
doaj   +1 more source

The secondary structure of apolipoprotein A-I on 9.6-nm reconstituted high-density lipoprotein determined by EPR spectroscopy. [PDF]

, 2013
Apolipoprotein A-I (ApoA-I) is the major protein component of high-density lipoprotein (HDL), and is critical for maintenance of cholesterol homeostasis.
Borja, Mark S, Budamagunta, Madhu S, Lagerstedt, Jens O, Oda, Michael N, Petrlova, Jitka, Voss, John C   +5 more
core   +1 more source

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Distribution and genetic characterization of fluoroquinolone resistance gene qnr among Salmonella strains from chicken in China

Microbiology Spectrum
The prevalence and dissemination of the plasmid-mediated fluoroquinolone (FQ) resistance gene qnr in Salmonella are considered serious public health concerns worldwide.
Yang Chen, Lihui Liu, Yali Guo, Jinhua Chu, Bangjuan Wang, Yuxin Sui, Hanqi Wei, Haihong Hao, Lingli Huang, Guyue Cheng   +9 more
doaj   +1 more source

Mutational and secondary structural analysis of the basolateral sorting signal of the polymeric immunoglobulin receptor. [PDF]

, 1993
The 17-juxtamembrane cytoplasmic residues of the polymeric immunoglobulin receptor contain an autonomous basolateral targeting signal that does not mediate rapid endocytosis (Casanova, J. E., G. Apodaca, and K. E. Mostov. Cell. 66:65-75).
Aroeti, B, Cohen, FE, Kosen, PA, Kuntz, ID, Mostov, KE   +4 more
core  

The Application of Hollow Fiber Cartridge in Biomedicine

Pharmaceutics, 2022
The hollow fiber cartridge has the advantages of good semi-permeability, high surface area to volume ratio, convenient operation, and so on. Its application in chemical analysis, drug in vitro experiment, hemodialysis, and other fields has been deeply ...
Yixuan Hou, Kun Mi, Lei Sun, Kaixiang Zhou, Lei Wang, Lan Zhang, Zhenli Liu, Lingli Huang   +7 more
doaj   +1 more source

Management of vegetable crop residues for reducing nitrate leaching losses in intensive vegetable rotations [PDF]

, 2012
Crop residues of field vegetables are often characterized by large amounts of biomass with a high N-content. Despite low soil temperatures during autumn, high rates of N mineralization and nitrification still occur causing important N-losses through ...
Agneessens, Laura, Crappé, Sara, De Neve, Stefaan, Elsen, Annemie, Goovaerts, Ellen, Van de Sande, Tomas, Vandecasteele, Bart   +6 more
core   +1 more source

Residues of Manifolds

The Journal of Geometric Analysis, 2023
The Riesz $z$-energy of a manifold $X$ is the integration of the distance between two points to the power $z$ over the product space $X\times X$. Considered as a function of a complex variable $z$, it can be generalized to a meromorphic function by analytic continuation, which we will call the meromorphic energy function of $X$.
openaire   +3 more sources

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait, R. Al‐Saadi, A. Lopez‐Cortes, K. Dzhuma, M. Oostveen, J. Brok, S. Irtan, M. Weeks, J. Bate, S. Baker, R. Williams, M. Powis, D. Saunders, O. Olsen, T. Watson, S. Shelmerdine, S. Vaidya, L. Howell, C. Duncan, G. M. Vujanic, C. Stiller, G. P. Balchin, T. Chowdhury, K. Pritchard‐Jones   +23 more
wiley   +1 more source

Fangchinoline demonstrates efficacy against TGEV through pAPN binding, as determined by preliminary toxicity evaluation

Animal Diseases
Through structure-based virtual screening, this study identified the botanical compound fangchinoline (FAN) as an inhibitor of the porcine aminopeptidase N (pAPN) receptor and evaluated its anti-transmissible gastroenteritis virus (TGEV) activity ...
Siyi Hu, Mengping Song, Yulu Wang, Jieying Zhang, Defeng Wen, Yanan Liu, Juncheng Chen, Jiali Wu, Yanfei Tao, Xu Wang   +9 more
doaj   +1 more source