Results 31 to 40 of about 409,543 (262)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Pedagogik: Jurnal PendidikanThe professional commitment of lecturers in higher education is increasingly under pressure due to publication demands, administrative burdens, and continuous performance-based evaluations.
Sofia Sofia +2 more
doaj +1 more source
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Conceptual Analysis Of Hybrid Cloud Vs. On-Premise Trade-Offs For Zero-Trust Auditing
Shodh SariThis conceptual study examines the performance-security trade-offs inherent in deploying Zero-Trust auditing frameworks across hybrid cloud and on-premise environments.
Mr. Venkatasubramanian Ganapathy
doaj +1 more source
Ecology and Society, 2023 Achieving sustainability in the Anthropocene requires radical changes to how human societies operate. The Seeds of Good Anthropocenes (SOGA) project has identified a diverse set of existing initiatives, called “seeds,” that have the potential to catalyze
Aaron J. Tuckey +7 more
doaj +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Journal of Pain Research, 2018 Marcia C Morete,1 João Paulo C Solano,2 Mario S Boff,3 Wilson J Filho,3 Hazem A Ashmawi3 1School of Medicine, University of São Paulo, Santos, São Paulo, Brazil; 2Department of Medicine, São Camilo University, São Paulo,
Morete MC +4 more
doaj
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Testicular and thyroid function as survival predictors in the elderly patient candidate to surgery
Monaldi Archives for Chest Disease, 2017 The relationship between testosterone deficiency (TD) syndrome and surgical resilience has a great impact in the modern approach to male elderly patients.
Antonio Aversa, Andrea Fabbri
doaj +1 more source