Results 41 to 50 of about 409,543 (262)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Relationship of Flexibility and Resilience with Islamic Work Ethics
Health, Spirituality and Medical Ethics, 2020 Background and Objectives: Islamic work ethics is influenced by several variables, such as some psychological components. In this regard, the present study aimed to investigate the relationship of flexibility and resilience with Islamic work ethics ...
Hossein Rostami +4 more
doaj
Scientific mobilization of keystone actors for biosphere stewardship
Scientific Reports, 2022 The biosphere crisis requires changes to existing business practices. We ask how corporations can become sustainability leaders, when constrained by multiple barriers to collaboration for biosphere stewardship.
Henrik Österblom +23 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Neuropsychiatric Disease and Treatment, 2020 Yirui Hu,1 Xin Chu,2 Thomas G Urosevich,3 Stuart N Hoffman,4 H Lester Kirchner,1 Richard E Adams,5 Ryan J Dugan,6 Joseph J Boscarino,7 Weixing Shi,2 Carrie A Withey,6 Charles R Figley,8 Joseph A Boscarino6 1Biomedical and Translational Informatics ...
Hu Y +11 more
doaj
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
VertigOSince the great droughts of the 1970s and even today, climate risks have been the major challenge facing by the main agricultural and pastoral activities in the Sahel and particularly in Niger.
Bouda Maja Chardi Moussa +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source