Results 31 to 40 of about 404,363 (263)

Two end-member earthquake preparations illuminated by foreshock activity on a meter-scale laboratory fault

Nature Communications, 2021
By tuning fault surface heterogeneity, the authors report earthquake preparation processes respectively driven by preslip and cascade-up on a meter-scale laboratory fault. The findings suggest that foreshock activity can be useful for predicting when and
Futoshi Yamashita, Eiichi Fukuyama, Shiqing Xu, Hironori Kawakata, Kazuo Mizoguchi, Shigeru Takizawa   +5 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Digital interventions to promote psychological resilience: a systematic review and meta-analysis

npj Digital Medicine
Societies are exposed to major challenges at an increasing pace. This underscores the need for preventive measures such as resilience promotion that should be available in time and without access barriers.
Sarah K. Schäfer, Lisa von Boros, Lea M. Schaubruch, Angela M. Kunzler, Saskia Lindner, Friederike Koehler, Tabea Werner, Federico Zappalà, Isabella Helmreich, Michèle Wessa, Klaus Lieb, Oliver Tüscher   +11 more
doaj   +1 more source

QAnon Conspiracy Theory: Examining its Evolution and Mechanisms of Radicalization

Journal for Deradicalization, 2021
This report demonstrates the overarching need for additional exploration and intervention of conspiracy-based radicalization as the QAnon conspiracy theory continues to grow.
Amanda Garry, Samantha Walther, Rukaya Rukaya, Ayan Mohammed   +3 more
doaj  

The problem of spatial fit in social-ecological systems: detecting mismatches between ecological connectivity and land management in an urban region

Ecology and Society, 2014
The problem of institutional fit in social-ecological systems has been empirically documented and conceptually discussed for decades, yet there is a shortage of approaches to systematically and quantitatively examine the level of fit. We address this gap,
Arvid Bergsten, Diego Galafassi, Örjan Bodin   +2 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Enhancing the Fit through Adaptive Co-management: Creating and Maintaining Bridging Functions for Matching Scales in the Kristianstads Vattenrike Biosphere Reserve, Sweden

Ecology and Society, 2007
In this article, we focus on adaptive governance of social-ecological systems (SES) and, more specifically, on social factors that can enhance the fit between governance systems and ecosystems. The challenge lies in matching multilevel governance system,
Per Olsson, Carl Folke, Victor Galaz, Thomas Hahn, Lisen Schultz   +4 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source