Results 41 to 50 of about 445,983 (219)

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Unified Scaling Law for Lengths of Basaltic Lava Flows: Dependence on Erupted Volume and Effusion Rate

Geophysical Research Letters
Morphological scaling laws for basaltic lava flows, linking flow dimensions and eruption conditions, are essential for hazard assessment and geological analysis of basaltic eruptions.
Takafumi Maruishi, Tomofumi Kozono, Takahiro Miwa, Eisuke Fujita   +3 more
doaj   +1 more source

The role of digital participation platforms in risk-informed development: A case study of Surabaya, Indonesia

Progress in Disaster Science
There is growing policy consensus around the need for development to be risk-informed. In parallel, digital technologies are increasingly deployed to enhance participation within a wide range of policy domains, particularly in urban settings.
Ronan McDermott, Saut Sagala, Nurulitha Andini Susetyo, Akhirul Insan, William Diondi Parasian Harahap, Annisaa Indrarini, Danang Azhari   +6 more
doaj   +1 more source

Adaptive Comanagement: a Systematic Review and Analysis

Ecology and Society, 2012
This paper outlines the results of a systematic review of the literature on adaptive comanagement (ACM). Adaptive comanagement is an emergent governance approach for complex social-ecological systems that links the learning function of adaptive ...
Ryan Plummer, Beatrice Crona, Derek R. Armitage, Per Olsson, Maria Tengö, Olga Yudina   +5 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Evidence of strong long-period ground motions of engineering importance for Nankai Trough plate boundary earthquakes: comparison of ground motions of two moderate-magnitude earthquakes

Earth, Planets and Space, 2018
We analyzed strong-motion and broadband recordings of two moderate-magnitude earthquakes that occurred in the Nankai Trough. The first event was the 2004 Mw 6.5 southeast off-Kii peninsula earthquake, an aftershock event inside the Philippine Sea Plate ...
Yadab P. Dhakal, Wataru Suzuki, Takeshi Kimura, Nobuyuki Morikawa, Takashi Kunugi, Shin Aoi   +5 more
doaj   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Australians recognise the effects of climate change but not its consequences for health system resilience and workforce capacity

Scientific Reports
Public perceptions of climate change impacts on health systems and the health workforce remain underexplored yet are vital for informing policy to improve system performance and resilience.
Carolynn L. Smith, Yvonne Zurynski, Louise A. Ellis, Georgia Fisher, Kate Churruca, Lisa Pagano, Samantha Spanos, Janet Long, Christina Rojas, Jeffrey Braithwaite   +9 more
doaj   +1 more source