Results 21 to 30 of about 32,086,790 (282)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Professional doctorates: applicability to the construction industry in increasing societal resilience to disasters [PDF]

, 2015
With the increase in occurrence of high impact disasters, the role of Higher Education Institutes (HEIs) in enhancing the disaster related knowledge and skills of construction professionals is highly recognised.
Amaratunga, Dilanthi, Haigh, Richard, Adeniyi, Onaopepo, Perera, Srinath (R18622), Perera, Srinath, Malalgoda, Chamindi, Keraminiyage, Kaushal   +6 more
core  

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Computational Materials: Preface

, 2004
10.1016/j.commatsci.2004.04.001Computational Materials Science303-4 SPEC.
Srolovitz, D., Philpott, Michael R., Feng, Y.P., Chen, K., Srolovitz, David, Wu, Ping, Wu, P., Feng, Yuan Ping, Philpott, M.R., Chen, Kan   +9 more
core   +1 more source

The Role of Government Policy in the Relationship Between Specialization Strategy and Business Resilience: Evidence from Indonesia’s Cosmetic Raw Materials Industry

Administrative Sciences
This study examines how government policy shapes the relationship between specialization strategy and business resilience in Indonesia’s cosmetic raw-materials industry.
Siu Min, Mts Arief, Sri Bramantoro Abdinagoro, Rano Kartono Rahim   +3 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Building Open Access to Research (OAR) Data Infrastructure at NIST

Data Science Journal, 2019
As a National Metrology Institute (NMI), the USA National Institute of Standards and Technology (NIST) scientists, engineers and technology experts conduct research across a full spectrum of physical science domains.
Gretchen Greene, Raymond Plante, Robert Hanisch   +2 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Nanoclustering in doped-lithium titanate and its effects on interfacial electrochemical kinetics

Applied Surface Science Advances
Doping has been widely applied to improve electrochemical kinetics of electrode materials in lithium-ion batteries. However, the complex behaviors of doping, e.g., dopant occupation in the lattice, clustering, and alteration of surface condition, are not
Ralph Nicolai Nasara, Che-An Lin, Kaviarasan Govindarajan, Rhaystie Blanco Sosa, Dmitry Pelegov, Wen-Dung Hsu, Ping-Chun Tsai, Takeshi Abe, Shih-Kang Lin   +8 more
doaj   +1 more source

World Agenda on Sustainable Recovery from the Covid-19 Pandemic: Recover Together, Recover Stronger

International Journal of Technology, 2021
For the first time, Indonesia will host the G20 Presidency in 2022 with the theme of "Recover Together, Recover Stronger", which reflects the spirit of collective global recovery needed after the world has struggled to deal with the Covid-19 pandemic
Mohammed Ali Berawi
doaj   +1 more source