Results 61 to 70 of about 1,189,370 (297)

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso   +5 more
wiley   +1 more source

Data, social sciences, and health resilience [PDF]

open access: yes, 2021
This STG Resilience Paper is part of the Commission Research Report and Interim Progress Report (June 2021) published by Reform for Resilience.There has been little health resilience in the face of the COVID-19 pandemic.
LEVINE, David K.
core   +1 more source

Predictive Resilience Modeling Using Statistical Regression Methods

open access: yesMathematics
Resilience describes the capacity of systems to react to, withstand, adjust to, and recover from disruptive events. Despite numerous metrics proposed to quantify resilience, few studies predict these metrics or the restoration time to nominal performance
Priscila Silva   +5 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

Measuring and optimizing the urban community resilience against public health emergencies: a case study in Nanjing, China

open access: yesFrontiers in Public Health
IntroductionUrban communities, as the basic unit of urban governance, play a crucial role in responding to public health emergencies (PHEs). This study aims to investigate the resilience measurement and optimization strategies of urban communities in ...
Peng Cui   +6 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

open access: yesFEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill   +6 more
wiley   +1 more source

Towards Resilience Metrics for Future Cloud Applications

open access: yesProceedings of the 6th International Conference on Cloud Computing and Services Science, 2016
An analysis of new technologies can yield insight into the way these technologies will be used. Inevitably, new technologies and their uses are likely to result in new security issues regarding threats, vulnerabilities and attack vectors. In this paper, we investigate and analyse technological and security trends and their potential to become future ...
Marko Novak   +7 more
openaire   +4 more sources

Short research report : exploring resilience development in a Taiwanese preschooler’s narrative : an emerging theoretical model [PDF]

open access: yes, 2016
Short Research Report:Exploring resilience development in a Taiwanese preschooler’s narrative: An emerging theoretical model.peer ...
Kuan-Ling Olivia Lin   +2 more
core   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

open access: yesFEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell   +8 more
wiley   +1 more source

Evaluation and Enhancement of Power System Resilience Under Weather Events

open access: yesEngineering Proceedings
Extreme weather events might harm power system equipment. Although these events are infrequent, their impact is substantial, making the power system and its modern grids vulnerable to weather-related conditions. In this study, we reviewed weather-related
Yuan-Kang Wu   +2 more
doaj   +1 more source

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