Results 111 to 120 of about 6,548,311 (348)

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Effects of 15-year straw incorporation on soil carbon composition and microbial community under wheat–maize rotation system in the Huang-Huai-Hai Plain

BMC Plant Biology
Background Straw incorporation is an effective agronomic practice for improving soil fertility and crop yield. In this study, we investigated the effects of the different straw incorporation modes on soil organic carbon components, enzyme activities, and
Xiang Chen, Zhiwei Tang, Ying Weng, Hongmei Cai, Yu Wu, Baoqiang Zheng, Jincai Li   +6 more
doaj   +1 more source

Resistance games [PDF]

Nature Ecology & Evolution, 2019
A game theory study supported by in vitro experimental data shows that drug treatment of non-small-cell lung cancer cells causes the cells to switch between evolutionary games they play among each other. Moreover, the work calls into question standard assumptions on the fitness costs of drug resistance to cancer cells.
openaire   +2 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Effects of maternal methyl donor intake during pregnancy on ileum methylation and function in an intrauterine growth restriction pig model

Journal of Animal Science and Biotechnology
Background Intrauterine growth retardation (IUGR) affects intestinal growth, morphology, and function, which leads to poor growth performance and high mortality.
Yan Lin, Jiangnan Wu, Yong Zhuo, Bin Feng, Zhengfeng Fang, Shengyu Xu, Jian Li, Hua Zhao, De Wu, Lun Hua, Lianqiang Che   +10 more
doaj   +1 more source

Statistical methods to derive efficacy estimates of anti-malarials for uncomplicated Plasmodium falciparum malaria: pitfalls and challenges

Malaria Journal, 2017
The Kaplan–Meier (K–M) method is currently the preferred approach to derive an efficacy estimate from anti-malarial trial data. In this approach event times are assumed to be continuous and estimates are generated on the assumption that there is only one
Prabin Dahal, Julie A. Simpson, Grant Dorsey, Philippe J. Guérin, Ric N. Price, Kasia Stepniewska   +5 more
doaj   +1 more source

The Resistance of Nisin to Penicillinase. [PDF]

, 1954
G. C. Cheeseman, N. J. Berridge, Paavo Roine, Nils Andreas Sörensen   +3 more
openalex   +1 more source

Antibiotic resistance: a rundown of a global crisis

Infection and Drug Resistance, 2018
The advent of multidrug resistance among pathogenic bacteria is imperiling the worth of antibiotics, which have previously transformed medical sciences.
B. Aslam, Wei Wang, M. Arshad, M. Khurshid, S. Muzammil, M. Rasool, M. A. Nisar, Ruman Farooq Alvi, M. A. Aslam, M. Qamar, M. Salamat, Z. Baloch   +11 more
semanticscholar   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source