Results 231 to 240 of about 11,899,956 (387)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

WHO priority pathogens, ESKAPE bacteria, and antimicrobial resistance surveillance in household wastewater, Gombe, Nigeria. [PDF]

Access Microbiol
Muhammad Z, Adamu MT, Garba L, Abdullahi Tawfiq U, Yusuf I.   +4 more
europepmc   +1 more source

Evolution of Resistance byHelicoverpa zea(Lepidoptera: Noctuidae) Infesting Insecticidal Crops in the Southern United States [PDF]

, 2015
Zaiqi Pan, David W. Onstad, Philip R. Crain, André Luiz Barreto Crespo, W. D. Hutchison, David Buntin, Pat Porter, Angus L. Catchot, D. R. Cook, Clint Pilcher, Lindsey Flexner, Laura S. Higgins   +11 more
openalex   +1 more source

Resist resistance

This thesis explores changes in swallowing and communication following total laryngectomy (removal of the voice box). Chapter 1 outlines the anatomy and physiology of the pharynx and larynx, along with the functional changes that occur after the surgery.
openaire   +1 more source

Origins and Evolution of Antibiotic Resistance

Microbiology and Molecular Biology Reviews, 1996
J. Davies, D. Davies
semanticscholar   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

QTL mapping of oat crown rust resistance in Australian fields and identification of a seedling resistance locus in oat line GS7. [PDF]

Theor Appl Genet
Nguyen DT, Lewis D, Henningsen EC, Su Z, Mago R, Sperschneider J, Dodds PN, Rattey A, Yimer BA, Klos KE, Figueroa M.   +10 more
europepmc   +1 more source

Resisting resistance to cancer immunotherapy [PDF]

Thoracic Cancer, 2018
Lam, Walter Sze‐Tung, Wang, Louis Zizhao, Roudi, Raheleh, Yong, Wei‐Peng, Syn, Nicholas L., Sundar, Raghav   +5 more
openaire   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Artemisinin resistance in Plasmodium falciparum malaria.

New England Journal of Medicine, 2009
A. Dondorp, F. Nosten, P. Yi, D. Das, A. P. Phyo, J. Tarning, K. Lwin., F. Ariey, Warunee Hanpithakpong, Sue J Lee, P. Ringwald, K. Silamut, M. Imwong, K. Chotivanich, Pharath Lim, T. Herdman, S. An, S. Yeung, P. Singhasivanon, N. Day, N. Lindegårdh, D. Socheat, N. White   +22 more
semanticscholar   +1 more source