Results 31 to 40 of about 3,014,748 (294)
FEBS Letters, EarlyView.Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi +3 more
wiley +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
A Characterization of Effective Resistance Metrics [PDF]
, 2017 We produce a characterization of finite metric spaces which are given by the effective resistance of a graph. This characterization is applied to the more general context of resistance metrics defined by Kigami. A countably infinite resistance metric gives rise to a sequence of finite, increasing graphs with invariant effective resistance. We show that
arxiv +1 more source
Edge State Transport in Separately Contacted Double-Layer Quantum Hall Systems [PDF]
Phys. Rev. B53 (1996) R16168, 1996 We develop a theory of edge state transport in separately contacted double-layer quantum Hall systems which are tuned close to the resonance condition for tunneling between the layers. When applied to the case where contact is made to only one layer, the theory gives a quantized Hall resistance and zero longitudinal resistance in both weak and strong ...
arxiv +1 more source
FEBS Letters, EarlyView.LHCPs are transported to the thylakoid membrane via the (cp)SRP pathway. This process involves a transit complex of (cp)SRP43, (cp)SRP54 and LHCP, which interacts with (cp)FtsY and Alb3 at the membrane. GTP hydrolysis by (cp)SRP54 and (cp)FtsY triggers complex dissociation.
Victor Zegarra +7 more
wiley +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Nature Ecology & Evolution, 2019 A game theory study supported by in vitro experimental data shows that drug treatment of non-small-cell lung cancer cells causes the cells to switch between evolutionary games they play among each other. Moreover, the work calls into question standard assumptions on the fitness costs of drug resistance to cancer cells.
openaire +3 more sources
Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms
FEBS Letters, EarlyView.Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze +3 more
wiley +1 more source
Resistance Maintained in Digital Organisms despite Guanine/Cytosine-Based Fitness Cost and Extended De-Selection: Implications to Microbial Antibiotics Resistance [PDF]
MOJ Proteomics & Bioinformatics 2(2): 00039 (2015), 2023 Antibiotics resistance has caused much complication in the treatment of diseases, where the pathogen is no longer susceptible to specific antibiotics and the use of such antibiotics are no longer effective for treatment. A recent study that utilizes digital organisms suggests that complete elimination of specific antibiotic resistance is unlikely after
arxiv
Temperature-dependent contact resistances in high-quality polymer field-effect transistors [PDF]
Appl. Phys. Lett. 84, 443 (2004), 2003 Contact resistances between organic semiconductors and metals can dominate the transport properties of electronic devices incorporating such materials. We report measurements of the parasitic contact resistance and the true channel resistance in bottom contact poly(3-hexylthiophene) (P3HT) field-effect transistors with channel lengths from 400 nm up to
arxiv +1 more source