Results 121 to 130 of about 1,259,159 (318)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Genetic Basis and Clonal Population Structure of Antibiotic Resistance in Campylobacter jejuni Isolated From Broiler Carcasses in Belgium

Frontiers in Microbiology, 2018
Human campylobacteriosis is the leading food-borne zoonosis in industrialized countries. This study characterized the clonal population structure, antimicrobial resistance profiles and occurrence of antimicrobial resistance determinants of a set of ...
Mohamed Elhadidy, Mohamed Elhadidy, William G. Miller, Hector Arguello, Avelino Álvarez-Ordóñez, Alexandra Duarte, Alexandra Duarte, Katelijne Dierick, Nadine Botteldoorn   +8 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

PRGminer: harnessing deep learning for the prediction of resistance genes involved in plant defense mechanisms

Frontiers in Plant Science
Plant resistance genes are crucial in plant defense systems against a variety of diseases and pests. These plant-specific genes encode proteins that identify particular molecular patterns associated with pathogens invading the plants.
Naveen Duhan, Naveen Duhan, Rakesh Kaundal, Rakesh Kaundal   +3 more
doaj   +1 more source

A high-resolution map of the Grp1 locus on chromosome V of potato harbouring broad-spectrum resistance to the cyst nematode species Globodera pallida and Globodera rostochiensis [PDF]

, 2009
The Grp1 locus confers broad-spectrum resistance to the potato cyst nematode species Globodera pallida and Globodera rostochiensis and is located in the GP21-GP179 interval on the short arm of chromosome V of potato.
Liesbeth Bouwman, Erin Bakker, Amelework Beyene, Dijk, T., van, Bakker, Erin, van Eck, Herman, Eck, H.J., van, van Eck, H.J., Anna Finkers-Tomczak, Overmars, H.A., Finkers-Tomczak, Anna, Jaap Bakker, Danan, S., Bakker, E.H., Finkers-Tomczak, A.M., Danan, Sarah, Overmars, Hein, Beyene, Amelework, Goverse, A., Aska Goverse, Goverse, Aska, Herman van Eck, Bouwman-Smits, L., Beyene, A., Bakker, J., van Dijk, T., Hein Overmars, van Dijk, Thijs, Bouwman, Liesbeth, Sarah Danan, Bakker, Jaap, Thijs van Dijk   +31 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Transcriptomics and metabolomics analyses provide insights into resistance genes of tree ferns

Frontiers in Genetics
As ancient organisms, tree ferns play a crucial role as an evolutionary bridge between lower and higher plant species, providing various utilitarian benefits.
Weicheng Yang, Qinqin He, Lijun Zhang, Jiaxing Xiao, Jiao Yang, Bingjie Che, BingChen Zhang, Handan Chen, Jiang Li, Yu Jiang   +9 more
doaj   +1 more source

Drug resistance to sulphadoxine-pyrimethamine in Plasmodium falciparum malaria in Mlimba, Tanzania. [PDF]

, 2006
BACKGROUND\ud \ud Sulphadoxine-pyrimethamine (SP) has been and is currently used for treatment of uncomplicated Plasmodium falciparum malaria in many African countries.
Mbugi, Erasto V, Balthazary Sakurani T, Malisa, Allen L, Mbugi Erasto V, Allen L Malisa, Nyambo, Thomas B, Nyambo, T.B., Mutayoba, B.M., Mutayoba Benezeth M, Nyambo Thomas B, Balthazary, Sakurani T, Erasto V Mbugi, Balthazary, S.T., Hassan Mshinda, Mshinda, H., Mshinda Hassan, Benezeth M Mutayoba, Sakurani T Balthazary, Malisa Allen L, Mutayoba, Benezeth M, Mbugi, E.V., Thomas B Nyambo, Mshinda, Hassan, Malisa, A.L.   +23 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Nanopore Sequencing-Driven Mapping of Antimicrobial Resistance Genes in Selected Escherichia coli Isolates from Pigs and Poultry Layers in Nigeria

Antibiotics
Background: Despite the huge burden of deaths associated with or attributable to antimicrobial resistance, studies on sequencing based antimicrobial resistance (AMR) monitoring in Africa are scarce, specifically in the animal sector.
Akinlabi Oladele Ogunleye, Prakash Ghosh, Adja Bousso Gueye, Foluke Olajumoke Jemilehin, Adelekan Oluseyi Okunlade, Veronica Olatimbo Ogunleye, Rea Maja Kobialka, Finja Rausch, Franziska Tanneberger, Adebowale Titilayo Philip Ajuwape, Ousmane Sow, George Olusegun Ademowo, Ulrike Binsker, Ahmed Abd El Wahed, Uwe Truyen, Yakhya Dieye, Cheikh Fall   +16 more
doaj   +1 more source