Results 251 to 260 of about 2,975,301 (351)

Defects in the necroptosis machinery are a cancer resistance mechanism to checkpoint inhibitor immunotherapy. [PDF]

J Immunother Cancer
Sax A, May P, Enssle S, Soliman N, Nedelko T, Mandracci G, Stögbauer F, Joachim L, Winter C, Bassermann F, Steiger K, El Khawanky N, Poeck H, Heidegger S.   +13 more
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Strategy to overcome a nirmatrelvir resistance mechanism in the SARS-CoV-2 nsp5 protease. [PDF]

Sci Adv
Neilsen G, Lan S, Slack RL, Lorson ZC, Emanuelli Castaner A, Lee R, Edwards KG, Zhang H, Lee J, Cantara WA, Cilento ME, Zhang H, De R, Amblard F, Tedbury PR, Kirby KA, Schinazi RF, Sarafianos SG.   +17 more
europepmc   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Genomic Characterization of Carbapenem-Resistant <i>Acinetobacter baumannii</i> in ICU Environments: Mobile Genetic Elements, Efflux Pumps, and Resistance Mechanism. [PDF]

Infect Drug Resist
Wang B, Wang W, Lu M, Jin H.
europepmc   +1 more source

RESISTANCE AND DNA REPAIR MECHANISMS UNDER NITROSATIVE STRESS IN MAMMALIAN AND MICROBIAL SYSTEMS

, 2010
Hyunwook Lee
openalex   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Integrated transcriptomic and metabolomic analysis of Jinggang honey pomelo yellow spot disease to reveal the disease resistance mechanism. [PDF]

PLoS One
Sun H, Li Z, Guo Y, Li W, Jin B, Lu L, Liu D, He L, Yin S, Wu Y.   +9 more
europepmc   +1 more source

Evidence for two arsenate resistance mechanisms in thiobacillus ferrooxidans

, 1995
S.N Barbi, Jacques R. Nicoli, Rogélio Lopes Brandão, Mônica Cristina Teixeira   +3 more
openalex   +1 more source