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Mechanisms of antibiotic resistance
Therapeutische Umschau, 2002Antibiotika interferieren mit strukturellen oder regulatorischen Elementen der Bakterienzelle und führen zum Wachstumsstillstand oder Tod der Zelle. Bakterien haben vielfältige Strategien entwickelt, um sich der Wirkung von Antibiotika zu entziehen. Beispiele sind enzymatische Spaltung der Substanz, Veränderung des Angriffspunkts, Efflux-Pumpen und ...
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Mechanisms of Polymyxin Resistance
2019Polymyxin antibiotics are increasingly being used as last-line therapeutic options against a number of multidrug resistant bacteria. These antibiotics show strong bactericidal activity against a range of Gram-negative bacteria, but with the increased use of these antibiotics resistant strains are emerging at an alarming rate.
Jennifer H, Moffatt +2 more
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Mechanisms of resistance to aminoglycosides
The American Journal of Medicine, 1977Bacterial resistance to aminoglycoside antibiotics occurs by a variety of mechanisms. In clinical situations the most common mechanism is plasmid-determined modification of the drug that leads to a block of transport of the antibiotic into the cell. Amikacin, a semisynthetic aminoglycoside, is effective against a number of resistant strains because it ...
J, Davies, P, Courvalin
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Resistance mechanisms in Enterobacteriaceae
Pathology, 2015Enterobacteriaceae are responsible for a large proportion of serious, life-threatening infections and resistance to multiple antibiotics in these organisms is an increasing global public health problem. Mutations in chromosomal genes contribute to antibiotic resistance, but Enterobacteriaceae are adapted to sharing genetic material and much important ...
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Epileptic Disorders, 2005
ABSTRACT Despite the use of new antiepileptic drugs, approximately one third of patients with epilepsy have seizures that cannot be controlled satisfactorily by medical treatment. Drug resistance may exist at the time of the first seizure or may develop later as result of the disease process.
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ABSTRACT Despite the use of new antiepileptic drugs, approximately one third of patients with epilepsy have seizures that cannot be controlled satisfactorily by medical treatment. Drug resistance may exist at the time of the first seizure or may develop later as result of the disease process.
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Mechanisms of fluoroquinolone resistance
Drug Resistance Updates, 1999Mechanisms of bacterial resistance to fluoroquinolones fall into two principal categories, alterations in drug target enzymes and alterations that limit permeation of drug to the target, both resulting from chromosomal mutations. No specific resistance mechanisms of quinolone degradation or modification have been found.
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Mechanisms of radiation resistance.
Rays, 1993[No abstract available]
C. Biagini +2 more
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Mechanisms of Resistance to Radiation
2012Radiotherapy is a very effective treatment for achieving local tumor control in breast cancer. However, intrinsic tumor cell radioresistance is a significant clinical problem that limits the results of the treatment. Chemotherapeutics that could specifically sensitize tumors to radiation would greatly increase the ability to deliver higher doses while ...
Serra Kamer, Beste Melek Atasoy
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Mechanisms of Quinolone resistance
Journal of Infection and Chemotherapy, 1997Quinolone resistance is induced by mutations on quinolone target enzymes such as gyrase and topo IV, and by mutations that prevent drug accumulation as a result of changes in outer membrane proteins and/or activation of drug-efflux pumps. Mutations on the target enzymes usually cause resistance to quinolones specifically, but mutations affecting drug ...
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1988
The efficacy of gold treatment in rheumatoid arthritis is hampered by toxicity, most prevalent in early phases, and unresponsiveness which can only be assessed after more than 6 months on therapy. There is some evidence that more severe disease increases the likelihood of drug resistance.
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The efficacy of gold treatment in rheumatoid arthritis is hampered by toxicity, most prevalent in early phases, and unresponsiveness which can only be assessed after more than 6 months on therapy. There is some evidence that more severe disease increases the likelihood of drug resistance.
openaire +2 more sources