Results 221 to 230 of about 1,378,575 (268)

Resistance mechanisms

Seminars in Respiratory Infections, 2002
During the past decade, there has been extensive investigation of bacterial resistance mechanisms. The interplay of genetic and antibiotic factors on antibiotic resistance are multiple and complex. Antibiotic resistance is the clinical expression of these factors.
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Mechanisms of tamoxifen resistance

Breast Cancer Research and Treatment, 1994
Though the antiestrogen tamoxifen prolongs disease-free and overall survival in the adjuvant setting, and induces remissions in over half of the patients with estrogen receptor positive metastatic disease, all patients eventually acquire tamoxifen resistance.
C K, Osborne, S A, Fuqua
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Mechanisms of Resistance to Quinolones

Drugs, 1993
Mechanisms of resistance to the quinolones have been described for several bacterial species, but mainly for Escherichia coli and Staphylococcus aureus. Two principal mechanisms have been described: 1) alteration of the DNA gyrase, which is the target site of the quinolones; and 2) diminished accumulation in the cell as a result of either decreased ...
E, Cambau, L, Gutmann
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Mechanisms of Resistance to Camptothecins

Annals of the New York Academy of Sciences, 2000
Abstract:Camptothecins are broad‐spectrum anticancer drugs that specifically target DNA topoisomerase I. Although the availability of camptothecins has had a significant impact on cancer therapeutics, de novo or acquired clinical resistance to camptothecins is common.
A, Saleem, T K, Edwards, Z, Rasheed, E H, Rubin   +3 more
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Bacteriophage resistance mechanisms

Nature Reviews Microbiology, 2010
Phages are now acknowledged as the most abundant microorganisms on the planet and are also possibly the most diversified. This diversity is mostly driven by their dynamic adaptation when facing selective pressure such as phage resistance mechanisms, which are widespread in bacterial hosts.
Simon J, Labrie, Julie E, Samson, Sylvain, Moineau   +2 more
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Metalloid Resistance Mechanisms

1998
Transport systems are intimately involved in both drug action and resistance. The targets of most drugs are intracellular, requiring the existence of drug uptake systems. The most common mechanism of resistance to drugs and antibiotics is through the expression of genes for extrusion systems that reduce the intracellular concentration to subtoxic ...
R, Mukhopadhyay, J, Li, H, Bhattacharjee, B P, Rosen   +3 more
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Mechanisms of resistance to antibiotics

Current Opinion in Chemical Biology, 2003
Microbial resistance to antibiotics is manifested by changes in antibiotic permeability, alteration of target molecules, enzymatic degradation of the antibiotics, and efflux of antimicrobials from the cytosol. Bacteria and other microorganisms use all of these mechanisms to evade the toxic effects of antibiotics.
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Mechanisms of Bacterial Resistance

Pediatric Clinics of North America, 1995
Antibiotic resistance is a growing problem in clinical pediatrics. Many of the agents traditionally used to treat pediatric pathogens are becoming less effective because of increasing bacterial resistance. In addition, many more children are immunocompromised because of primary or acquired immunodeficiencies and because of advances in cancer ...
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Mechanisms of resistance to cisplatin

1991
A number of changes have been detected in cisplatin-resistant cells, some of which are likely to be directly involved in the mechanism of resistance. The four most cited mechanisms are reduced accumulation, increased glutathione, increased metallothionein, and enhanced DNA repair.
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Mechanisms of steroid resistance

Cell, 1974
Abstract A method is described for the rapid determination of binding capacity and subcellular distribution of radioactive dexamethasone by cultured lymphoma cells. Using it, a number of steroid-resistant lymphoma cell clones were shown to be deficient in steroid binding to specific cytoplasmic receptors (r-) in transfer of the receptor-steroid ...
Sibley, C H, Tomkins, G M
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