Results 211 to 220 of about 1,378,575 (268)

<i>BRAF</i> Fusion as Resistance Mechanism to Osimertinib in <i>EGFR</i>-Mutated NSCLC: A Case Report and Review of Literature. [PDF]

open access: yesJTO Clin Res Rep
Peroni M   +11 more
europepmc   +1 more source

<i>Aspergillus terreus</i> sectorization: a morphological phenomenon shedding light on amphotericin B resistance mechanism. [PDF]

open access: yesmBio
Eisele D   +10 more
europepmc   +1 more source

Mechanisms of aspirin resistance

Pharmacology & Therapeutics, 2014
Aspirin is integral to the secondary prevention of cardiovascular disease and acts to impair the development of platelet-mediated atherothromboembolic events by irreversible inhibition of platelet cyclooxygenase-1 (COX-1). Inhibition of this enzyme prevents the synthesis of the potent pro-aggregatory prostanoid thromboxane A2.
Floyd, Christopher N., Ferro, Albert
openaire   +3 more sources

Mechanisms of quinolone resistance

Infection, 1994
Two mechanisms of resistance to fluoroquinolones are known: (i) alteration of the molecular target of quinolone action-DNA gyrase, and (ii) reduction of the quinolone accumulation. Mutations altering the N-terminus of the gyrase A subunit, especially those around residues Ser83 and Asp87, significantly reduce the susceptibilities towards all quinolones,
B, Wiedemann, P, Heisig
openaire   +2 more sources

Mechanisms of resistance to cisplatin

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2001
The use of cisplatin in cancer chemotherapy is limited by acquired or intrinsic resistance of cells to the drug. Cisplatin enters the cells and its chloride ligands are replaced by water, forming aquated species that react with nucleophilic sites in cellular macromolecules.
M, Kartalou, J M, Essigmann
openaire   +2 more sources

Mechanisms of resistance to rapamycins

Drug Resistance Updates, 2001
Rapamycins represent a novel family of anticancer agents, currently including rapamycin and its derivatives, CCI-779 and RAD001. Rapamycins inhibit the function of the mammalian target of rapamycin (mTOR), and potently suppress tumor cell growth by arresting cells in G1 phase or potentially inducing apoptosis of cells, in culture or in xenograft tumor ...
S, Huang, P J, Houghton
openaire   +2 more sources

Home - About - Disclaimer - Privacy