<i>BRAF</i> Fusion as Resistance Mechanism to Osimertinib in <i>EGFR</i>-Mutated NSCLC: A Case Report and Review of Literature. [PDF]
Peroni M +11 more
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<i>Aspergillus terreus</i> sectorization: a morphological phenomenon shedding light on amphotericin B resistance mechanism. [PDF]
Eisele D +10 more
europepmc +1 more source
A novel acquired resistance mechanism to 5-aminolevulinic acid-mediated photodynamic therapy with ABCG2 inhibition. [PDF]
Chandratre S, Olsen J, Chen B.
europepmc +1 more source
Constructing a Novel Disease Resistance Mechanism Model for Cruciferous Crops: An Example From Black Rot. [PDF]
Dai H +9 more
europepmc +1 more source
Chemical corrosion resistance mechanism of titanium alloy radiation rods with self-protected structure. [PDF]
Cao H, Dong F, Zhang Q, Wu H.
europepmc +1 more source
Editorial: Studying plant virus-host interactions: elucidating the natural resistance mechanism. [PDF]
Kumar RV, Gnanasekaran P.
europepmc +1 more source
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Mechanisms of aspirin resistance
Pharmacology & Therapeutics, 2014Aspirin is integral to the secondary prevention of cardiovascular disease and acts to impair the development of platelet-mediated atherothromboembolic events by irreversible inhibition of platelet cyclooxygenase-1 (COX-1). Inhibition of this enzyme prevents the synthesis of the potent pro-aggregatory prostanoid thromboxane A2.
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Mechanisms of quinolone resistance
Infection, 1994Two mechanisms of resistance to fluoroquinolones are known: (i) alteration of the molecular target of quinolone action-DNA gyrase, and (ii) reduction of the quinolone accumulation. Mutations altering the N-terminus of the gyrase A subunit, especially those around residues Ser83 and Asp87, significantly reduce the susceptibilities towards all quinolones,
B, Wiedemann, P, Heisig
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Mechanisms of resistance to cisplatin
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2001The use of cisplatin in cancer chemotherapy is limited by acquired or intrinsic resistance of cells to the drug. Cisplatin enters the cells and its chloride ligands are replaced by water, forming aquated species that react with nucleophilic sites in cellular macromolecules.
M, Kartalou, J M, Essigmann
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Mechanisms of resistance to rapamycins
Drug Resistance Updates, 2001Rapamycins represent a novel family of anticancer agents, currently including rapamycin and its derivatives, CCI-779 and RAD001. Rapamycins inhibit the function of the mammalian target of rapamycin (mTOR), and potently suppress tumor cell growth by arresting cells in G1 phase or potentially inducing apoptosis of cells, in culture or in xenograft tumor ...
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