Results 301 to 310 of about 2,975,301 (351)

Bacteriophage resistance mechanisms

Nature Reviews Microbiology, 2010
Phages are now acknowledged as the most abundant microorganisms on the planet and are also possibly the most diversified. This diversity is mostly driven by their dynamic adaptation when facing selective pressure such as phage resistance mechanisms, which are widespread in bacterial hosts.
Simon J, Labrie, Julie E, Samson, Sylvain, Moineau   +2 more
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Mechanisms of tamoxifen resistance

Breast Cancer Research and Treatment, 1994
Though the antiestrogen tamoxifen prolongs disease-free and overall survival in the adjuvant setting, and induces remissions in over half of the patients with estrogen receptor positive metastatic disease, all patients eventually acquire tamoxifen resistance.
C K, Osborne, S A, Fuqua
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Metalloid Resistance Mechanisms

1998
Transport systems are intimately involved in both drug action and resistance. The targets of most drugs are intracellular, requiring the existence of drug uptake systems. The most common mechanism of resistance to drugs and antibiotics is through the expression of genes for extrusion systems that reduce the intracellular concentration to subtoxic ...
R, Mukhopadhyay, J, Li, H, Bhattacharjee, B P, Rosen   +3 more
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Resistance mechanisms

Seminars in Respiratory Infections, 2002
During the past decade, there has been extensive investigation of bacterial resistance mechanisms. The interplay of genetic and antibiotic factors on antibiotic resistance are multiple and complex. Antibiotic resistance is the clinical expression of these factors.
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Microbial radiation-resistance mechanisms

Journal of Microbiology, 2017
Organisms living in extreme environments have evolved a wide range of survival strategies by changing biochemical and physiological features depending on their biological niches. Interestingly, organisms exhibiting high radiation resistance have been discovered in the three domains of life (Bacteria, Archaea, and Eukarya), even though a naturally ...
Kwang-Woo, Jung, Sangyong, Lim, Yong-Sun, Bahn   +2 more
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Mechanisms of quinolone resistance

Infection, 1994
Two mechanisms of resistance to fluoroquinolones are known: (i) alteration of the molecular target of quinolone action-DNA gyrase, and (ii) reduction of the quinolone accumulation. Mutations altering the N-terminus of the gyrase A subunit, especially those around residues Ser83 and Asp87, significantly reduce the susceptibilities towards all quinolones,
B, Wiedemann, P, Heisig
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Mechanisms of aspirin resistance

Pharmacology & Therapeutics, 2014
Aspirin is integral to the secondary prevention of cardiovascular disease and acts to impair the development of platelet-mediated atherothromboembolic events by irreversible inhibition of platelet cyclooxygenase-1 (COX-1). Inhibition of this enzyme prevents the synthesis of the potent pro-aggregatory prostanoid thromboxane A2.
Floyd, Christopher N., Ferro, Albert
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Mechanisms of Quinolone resistance

Journal of Infection and Chemotherapy, 1997
Quinolone resistance is induced by mutations on quinolone target enzymes such as gyrase and topo IV, and by mutations that prevent drug accumulation as a result of changes in outer membrane proteins and/or activation of drug-efflux pumps. Mutations on the target enzymes usually cause resistance to quinolones specifically, but mutations affecting drug ...
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Mechanisms of steroid resistance

Cell, 1974
Abstract A method is described for the rapid determination of binding capacity and subcellular distribution of radioactive dexamethasone by cultured lymphoma cells. Using it, a number of steroid-resistant lymphoma cell clones were shown to be deficient in steroid binding to specific cytoplasmic receptors (r-) in transfer of the receptor-steroid ...
Sibley, C H, Tomkins, G M
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Mechanisms of antibiotic resistance

Therapeutische Umschau, 2002
Antibiotika interferieren mit strukturellen oder regulatorischen Elementen der Bakterienzelle und führen zum Wachstumsstillstand oder Tod der Zelle. Bakterien haben vielfältige Strategien entwickelt, um sich der Wirkung von Antibiotika zu entziehen. Beispiele sind enzymatische Spaltung der Substanz, Veränderung des Angriffspunkts, Efflux-Pumpen und ...
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